SMC6 Antikörper (AA 309-450)

Produktnummer ABIN7170874

Produktdetails anti-SMC6 Antikörper

Target: SMC6 (SMC6 Structural Maintenance of Chromosomes 6-Like 1 (SMC6))

Bindungsspezifität: AA 309-450

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMC6 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Structural maintenance of chromosomes protein 6 protein (309-450AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:200-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SMC6

Target: SMC6 (SMC6 Structural Maintenance of Chromosomes 6-Like 1 (SMC6))

Andere Bezeichnung: SMC6 (SMC6 Produkte)

Synonyme: SMC6L1 antikoerper, SMC-6 antikoerper, hSMC6 antikoerper, 2810489L22Rik antikoerper, 3830418C19Rik antikoerper, AA990493 antikoerper, AU018782 antikoerper, AW742439 antikoerper, Smc6l1 antikoerper, mKIAA4103 antikoerper, structural maintenance of chromosomes 6 antikoerper, SMC6 antikoerper, smc6 antikoerper, Smc6 antikoerper

Hintergrund:

Background: Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541).

Aliases: FLJ22116 antibody, FLJ35534 antibody, hSMC6 antibody, SMC 6 antibody, SMC protein 6 antibody, SMC-6 antibody, SMC6 antibody, SMC6 protein antibody, SMC6 structural maintenance of chromosomes 6 like 1 antibody, SMC6_HUMAN antibody, Smc6l1 antibody, Structural maintenance of chromosomes 6 antibody, Structural maintenance of chromosomes 6 like 1 antibody, Structural maintenance of chromosomes protein 6 antibody

UniProt: Q96SB8