TDP1 Antikörper (AA 1-608)

Produktnummer ABIN565920

Dieses Anti-TDP1-Antikörper ist ein Maus Polyklonal-Antikörper zur Detektion von TDP1 in WB und ELISA. Geeignet für Human. Dieses Primary Antibody wurde in 5+ Publikationen zitiert.

Kurzübersicht für TDP1 Antikörper (AA 1-608) (ABIN565920)

Target: TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))

Reaktivität: Human

Wirt: Maus

Klonalität: Polyklonal

Konjugat: Dieser TDP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-TDP1 Antikörper

Bindungsspezifität: AA 1-608

Verwendungszweck: Mouse polyclonal antibody raised against a full-length recombinant TDP1.

Sequenz: MSQEGDYGRW TISSSDESEE EKPKPDKPST SSLLCARQGA ANEPRYTCSE AQKAAHKRKI SPVKFSNTDS VLPPKRQKSG SQEDLGWCLS SSDDELQPEM PQKQAEKVVI KKEKDISAPN DGTAQRTENH GAPACHRLKE EEDEYETSGE GQDIWDMLDK GNPFQFYLTR VSGVKPKYNS GALHIKDILS PLFGTLVSSA QFNYCFDVDW LVKQYPPEFR KKPILLVHGD KREAKAHLHA QAKPYENISL CQAKLDIAFG THHTKMMLLL YEEGLRVVIH TSNLIHADWH QKTQGIWLSP LYPRIADGTH KSGESPTHFK ADLISYLMAY NAPSLKEWID VIHKHDLSET NVYLIGSTPG RFQGSQKDNW GHFRLKKLLK DHASSMPNAE SWPVVGQFSS VGSLGADESK WLCSEFKESM LTLGKESKTP GKSSVPLYLI YPSVENVRTS LEGYPAGGSL PYSIQTAEKQ NWLHSYFHKW SAETSGRSNA MPHIKTYMRP SPDFSKIAWF LVTSANLSKA AWGALEKNGT QLMIRSYELG VLFLPSAFGL DSFKVKQKFF AGSQEPMATF PVPYDLPPEL YGSKDRPWIW NIPYVKAPDT HGNMWVPS

Kreuzreaktivität: Human

Produktmerkmale: Antibody Reactive Against Recombinant Protein.

Immunogen: TDP1 (AAH15474.1, 1 a.a. ~ 608 a.a) full-length recombinant protein with GST tag.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 50 % glycerol

Handhabung: Aliquot to avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

Referenzen für anti-TDP1 Antikörper (ABIN565920)

Das, Huang, Murai, Rehman, Amé, Sengupta, Das, Majumdar, Zhang, Biard, Majumder, Schreiber, Pommier: "PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage." in: Nucleic acids research, Vol. 42, Issue 7, pp. 4435-49, (2014) (PubMed).

Katyal, Lee, Nitiss, Downing, Li, Shimada, Zhao, Russell, Petrini, Nitiss, McKinnon: "Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes." in: Nature neuroscience, Vol. 17, Issue 6, pp. 813-21, (2014) (PubMed).

Hawkins, Subler, Akopiants, Wiley, Taylor, Rice, Windle, Valerie, Povirk: "In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutation." in: DNA repair, Vol. 8, Issue 5, pp. 654-63, (2009) (PubMed).

Das, Antony, Gupta, Dexheimer, Redon, Garfield, Shiloh, Pommier: "Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK." in: The EMBO journal, Vol. 28, Issue 23, pp. 3667-80, (2009) (PubMed).

Katyal, el-Khamisy, Russell, Li, Ju, Caldecott, McKinnon: "TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo." in: The EMBO journal, Vol. 26, Issue 22, pp. 4720-31, (2007) (PubMed).

Details zu TDP1

Target: TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))

Andere Bezeichnung: TDP1

Hintergrund: Full Gene Name: tyrosyl-DNA phosphodiesterase 1
Synonyms: FLJ11090,MGC104252

Gen-ID: 55775