SIRT1 Antikörper (AA 456-555)

Produktnummer ABIN565071

Dieses Anti-SIRT1-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von SIRT1 in WB, ELISA, IF und IHC (p). Geeignet für Human. Dieses Primary Antibody wurde in 3+ Publikationen zitiert.

Kurzübersicht für SIRT1 Antikörper (AA 456-555) (ABIN565071)

Target: SIRT1 (Sirtuin 1 (SIRT1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SIRT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 7B7

Produktdetails anti-SIRT1 Antikörper

Bindungsspezifität: AA 456-555

Verwendungszweck: Mouse monoclonal antibody raised against a partial recombinant SIRT1.

Sequenz: NRYIFHGAEV YSDSEDDVLS SSSCGSNSDS GTCQSPSLEE PMEDESEIEE FYNGLEDEPD VPERAGGAGF GTDGDDQEAI NEAISVKQEV TDMNYPSNKS

Kreuzreaktivität: Human

Produktmerkmale: Antibody Reactive Against Recombinant Protein.

Immunogen: SIRT1 (AAH12499, 456 a.a. ~ 555 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1x PBS, pH 7.4

Handhabung: Aliquot to avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

Referenzen für anti-SIRT1 Antikörper (ABIN565071)

Kok, Lin, Hou, Hong, Chang, Hsiao, Wang, Lai, Lin: "Simvastatin inhibits cysteine-rich protein 61 expression in rheumatoid arthritis synovial fibroblasts through the regulation of sirtuin-1/FoxO3a signaling." in: Arthritis and rheumatism, Vol. 65, Issue 3, pp. 639-49, (2013) (PubMed).

Østrup, Hyttel, Klærke, Collas: "Remodeling of ribosomal genes in somatic cells by Xenopus egg extract." in: Biochemical and biophysical research communications, Vol. 412, Issue 3, pp. 487-93, (2011) (PubMed).

Hiraike, Wada-Hiraike, Nakagawa, Koyama, Miyamoto, Sone, Tanikawa, Tsuruga, Nagasaka, Matsumoto, Oda, Shoji, Fukuhara, Saji, Nakagawa, Kato, Yano, Taketani: "Identification of DBC1 as a transcriptional repressor for BRCA1." in: British journal of cancer, Vol. 102, Issue 6, pp. 1061-7, (2010) (PubMed).

Details zu SIRT1

Target: SIRT1 (Sirtuin 1 (SIRT1))

Andere Bezeichnung: SIRT1

Hintergrund: Full Gene Name: sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)
Synonyms: SIR2L1

Gen-ID: 23411

Pathways: MAPK Signalweg, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Carbohydrate Homeostasis, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Negative Regulation of intrinsic apoptotic Signaling