PD-L1 Antikörper (AA 41-69)

Produktnummer ABIN5647488

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PD-L1 in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für PD-L1 Antikörper (AA 41-69) (ABIN5647488)

Target: PD-L1 (CD274 (PD-L1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PD-L1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PD-L1 Antikörper

Bindungsspezifität: AA 41-69

Aufreinigung: Antigen affinity purified

Immunogen: Amino acids 41-69 (KFPVEKQLDLAALIVYWEMEDKNIIQFVH-human) were used as the immunogen for the B7-H1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the B7-H1 antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the B7-H1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu PD-L1

Target: PD-L1 (CD274 (PD-L1))

Andere Bezeichnung: PD-L1 / B7-H1 / CD274

Hintergrund: B7 Homolog 1 (B7-H1), also known as CD274 or PD-L1, is a protein that in humans is encoded by the CD274 gene. It is mapped to 9p24.1. B7-H1 is a 40 kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis. It has been concluded that upregulation of B7-H1 on tumor MDCs downregulates T-cell immunity and that B7-H1 blockade may represent an approach for cancer immunotherapy. Additionally, B7-H1 can provide positive costimulatory signals for innate and adaptive immunity and for protection against intracellular bacterial infection.

UniProt: Q9NZQ7

Pathways: Cancer Immune Checkpoints