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PD-L1 Antikörper (PE)

PD-L1 Reaktivität: Human, Non-Human Primate FACS, Func, IHC (fro) Wirt: Maus Monoclonal 29E-2A3 PE
Produktnummer ABIN5665753
$484.24
Zzgl. Versandkosten $45.00
100 tests
Lieferung in 5 bis 7 Werktagen
  • Target Alle PD-L1 Antikörper anzeigen
    PD-L1 (CD274 (PD-L1))
    Reaktivität
    • 171
    • 115
    • 69
    • 7
    • 6
    • 5
    • 4
    • 1
    • 1
    Human, Non-Human Primate
    Wirt
    • 129
    • 56
    • 18
    • 8
    • 2
    • 1
    Maus
    Klonalität
    • 123
    • 90
    • 1
    Monoklonal
    Konjugat
    • 96
    • 17
    • 12
    • 12
    • 8
    • 6
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Dieser PD-L1 Antikörper ist konjugiert mit PE
    Applikation
    • 101
    • 91
    • 65
    • 44
    • 40
    • 27
    • 17
    • 15
    • 14
    • 13
    • 10
    • 10
    • 7
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Spezifität
    The mouse monoclonal antibody 29E.2A3 recognizes CD274 / PD-L1 (also known as B7-H1), a 40 kDa type I transmembrane protein expressed by dendritic cells, activated T cells, activated monocytes, and in various tissues, above all in heart and skeletal muscle, placenta and lung, and in many cancer cells, including T cell lymphomas, melanomas, and glioblastomas.
    Kreuzreaktivität (Details)
    Human, Non-Human Primates
    Immunogen
    Full length human CD274
    Klon
    29E-2A3
    Isotyp
    IgG2b
  • Applikationshinweise
    The reagent is designed for Flow Cytometry analysis of human blood cells using 10 μ,l reagent / 100 μ,l of whole blood or 106 cells in a suspension.The content of a vial (1 ml) is sufficient for 100 tests.
    Kommentare

    The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide.
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
  • Target
    PD-L1 (CD274 (PD-L1))
    Andere Bezeichnung
    CD274 / PD-L1 (PD-L1 Produkte)
    Synonyme
    B7-H antikoerper, B7H1 antikoerper, PD-L1 antikoerper, PDCD1L1 antikoerper, PDCD1LG1 antikoerper, PDL1 antikoerper, A530045L16Rik antikoerper, B7h1 antikoerper, Pdcd1l1 antikoerper, Pdcd1lg1 antikoerper, Pdl1 antikoerper, RGD1566211 antikoerper, CD274 molecule antikoerper, CD274 antigen antikoerper, programmed cell death 1 ligand 2 antikoerper, CD274 antikoerper, Cd274 antikoerper, PDCD1LG2 antikoerper
    Hintergrund
    CD274 / PD-L1 (programmed death ligand-1), also known as B7-H1, is a member of the B7 family of regulatory proteins. It can act as both costimulatory and coinhibitory molecule for T cells. Interaction with its ligand CD279 (PD1) appears to be important in the maintenance of peripheral tolerance and in prevention of tumor rejection. Even pathogens (e.g. Schistosoma) may exploit CD274 to evade an immune response. Besides CD279, existence of other receptor(s) for CD274 is likely.
    Pathways
    Cancer Immune Checkpoints
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