IL1RAP Antikörper (AA 484-518)

Produktnummer ABIN5647163

Der Kaninchen Polyklonal anti-IL1RAP Antikörper (ABIN5647163) detektiert spezifisch IL1RAP in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Maus.

Kurzübersicht für IL1RAP Antikörper (AA 484-518) (ABIN5647163)

Target: IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL1RAP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-IL1RAP Antikörper

Bindungsspezifität: AA 484-518

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 484-518 from human IL1RAP was used as the immunogen for the IL1RAP antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the IL1RAP antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. WB: 1:1000-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the IL1RAP antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu IL1RAP

Target: IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))

Andere Bezeichnung: IL1RAP

Hintergrund: Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1- dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone, binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non- signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand- bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B, this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

UniProt: Q9NPH3

Pathways: NF-kappaB Signalweg, Growth Factor Binding