RRM2 Antikörper (AA 1-110)

Produktnummer ABIN562744

Dieses Maus Monoklonal-Antikörper erkennt spezifisch RRM2 in WB, ELISA, IF, IP und IHC (p). Er zeigt eine Reaktivität gegenüber Human und wurde in 5+ Publikationen erwähnt.

Kurzübersicht für RRM2 Antikörper (AA 1-110) (ABIN562744)

Target: RRM2 (Ribonucleotide Reductase M2 (RRM2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser RRM2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 1E1

Produktdetails anti-RRM2 Antikörper

Bindungsspezifität: AA 1-110

Verwendungszweck: Mouse monoclonal antibody raised against a partial recombinant RRM2.

Sequenz: MLSLRVPLAP ITDPQQLQLS PLKGLSLVDK ENTPPALSGT RVLASKTARR IFQEPTEPKT KAAAPGVEDE PLLRENPRRF VIFPIEYHDI WQMYKKAEAS FWTAEEVDLS

Kreuzreaktivität: Human

Produktmerkmale: Antibody Reactive Against Recombinant Protein.

Immunogen: RRM2 (NP_001025, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1x PBS, pH 7.4

Handhabung: Aliquot to avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

Referenzen für anti-RRM2 Antikörper (ABIN562744)

Castelblanco, Zafon, Maravall, Gallel, Martinez, Capel, Bella, Halperin, Temprana, Iglesias, Puig-Domingo, Robledo, Matias-Guiu, Mauricio: "APLP2, RRM2, and PRC1: New Putative Markers for the Differential Diagnosis of Thyroid Follicular Lesions." in: Thyroid : official journal of the American Thyroid Association, Vol. 27, Issue 1, pp. 59-66, (2016) (PubMed).

Kim, Park, Joo, Shen, Hong, Kim, Singh, Lee, Shin: "RRM1 maintains centrosomal integrity via CHK1 and CDK1 signaling during replication stress." in: Cancer letters, Vol. 346, Issue 2, pp. 249-56, (2014) (PubMed).

Yoshida, Tsunoda, Doi, Tanaka, Fujimoto, Machida, Ota, Koyanagi, Takashima, Sasazuki, Kuroki, Iwasaki, Shirasawa: "KRAS-mediated up-regulation of RRM2 expression is essential for the proliferation of colorectal cancer cell lines." in: Anticancer research, Vol. 31, Issue 7, pp. 2535-9, (2011) (PubMed).

Zhou, Snyder, Lieberman: "Epstein-Barr virus episome stability is coupled to a delay in replication timing." in: Journal of virology, Vol. 83, Issue 5, pp. 2154-62, (2009) (PubMed).

Tang, Deng, Wang, Dai, Wang, Jiang, Li, Li, Sheng, Wu, Li, Zeng et al.: "Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in ..." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 11, pp. 1952-67, (2007) (PubMed).

Details zu RRM2

Target: RRM2 (Ribonucleotide Reductase M2 (RRM2))

Andere Bezeichnung: RRM2

Hintergrund: Full Gene Name: ribonucleotide reductase M2 polypeptide
Synonyms: R2,RR2M

Gen-ID: 6241

NCBI Accession: NM_001034

Pathways: Mitotic G1-G1/S Phases