RAB27A Antikörper (AA 122-221)

Produktnummer ABIN562560

Dieses Anti-RAB27A-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von RAB27A in WB, ELISA, IHC (p) und RNAi. Geeignet für Human. Dieses Primary Antibody wurde in 8+ Publikationen zitiert.

Kurzübersicht für RAB27A Antikörper (AA 122-221) (ABIN562560)

Target: RAB27A (RAB27A, Member RAS Oncogene Family (RAB27A))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser RAB27A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), RNA Interference (RNAi)

Klon: 1G7

Produktdetails anti-RAB27A Antikörper

Bindungsspezifität: AA 122-221

Verwendungszweck: Mouse monoclonal antibody raised against a partial recombinant RAB27A.

Sequenz: YCENPDIVLC GNKSDLEDQR VVKEEEAIAL AEKYGIPYFE TSAANGTNIS QAIEMLLDLI MKRMERCVDK SWIPEGVVRS NGHASTDQLS EEKEKGACGC

Kreuzreaktivität: Human

Produktmerkmale: Antibody Reactive Against Recombinant Protein.

Immunogen: RAB27A (NP_004571, 122 a.a. ~ 221 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1x PBS, pH 7.4

Handhabung: Aliquot to avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

Referenzen für anti-RAB27A Antikörper (ABIN562560)

Felicetti, De Feo, Coscia, Puglisi, Pedini, Pasquini, Bellenghi, Errico, Pagani, Carè: "Exosome-mediated transfer of miR-222 is sufficient to increase tumor malignancy in melanoma." in: Journal of translational medicine, Vol. 14, pp. 56, (2016) (PubMed).

Hannafon, Carpenter, Berry, Janknecht, Dooley, Ding: "Exosome-mediated microRNA signaling from breast cancer cells is altered by the anti-angiogenesis agent docosahexaenoic acid (DHA)." in: Molecular cancer, Vol. 14, pp. 133, (2015) (PubMed).

Cetica, Hackmann, Grieve, Sieni, Ciambotti, Coniglio, Pende, Gilmour, Romagnoli, Griffiths, Aricò: "Patients with Griscelli syndrome and normal pigmentation identify RAB27A mutations that selectively disrupt MUNC13-4 binding." in: The Journal of allergy and clinical immunology, (2014) (PubMed).

Kimura, Yamaoka, Taniguchi, Okamoto, Takei, Ando, Iwamatsu, Watanabe, Kaibuchi, Ishizaki, Niki: "Activated Cdc42-bound IQGAP1 determines the cellular endocytic site." in: Molecular and cellular biology, Vol. 33, Issue 24, pp. 4834-43, (2013) (PubMed).

Peinado, Ale?kovi?, Lavotshkin, Matei, Costa-Silva, Moreno-Bueno, Hergueta-Redondo, Williams, García-Santos, Ghajar, Nitadori-Hoshino, Hoffman, Badal, Garcia, Callahan, Yuan, Martins, Skog, Kaplan et al.: "Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. ..." in: Nature medicine, Vol. 18, Issue 6, pp. 883-91, (2012) (PubMed).

Sanchez-Ruiz, Valitutti, Dupre: "Stepwise maturation of lytic granules during differentiation and activation of human CD8+ T lymphocytes." in: PLoS ONE, Vol. 6, Issue 11, pp. e27057, (2011) (PubMed).

Neumüller, Hoffmeister, Babica, Prelle, Gegenbauer, Smolenski: "Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets." in: Blood, Vol. 114, Issue 7, pp. 1396-404, (2009) (PubMed).

Kimura, Kaneko, Yamada, Ishihara, Senda, Iwamatsu, Niki: "The GDP-dependent Rab27a effector coronin 3 controls endocytosis of secretory membrane in insulin-secreting cell lines." in: Journal of cell science, Vol. 121, Issue Pt 18, pp. 3092-8, (2008) (PubMed).

Details zu RAB27A

Target: RAB27A (RAB27A, Member RAS Oncogene Family (RAB27A))

Andere Bezeichnung: RAB27A

Hintergrund: Full Gene Name: RAB27A, member RAS oncogene family
Synonyms: GS2,HsT18676,MGC117246,RAB27,RAM

Gen-ID: 5873

NCBI Accession: NM_004580

Pathways: Peptide Hormone Metabolism