Axin Antikörper (AA 546-752)
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- Target Alle Axin (AXIN1) Antikörper anzeigen
- Axin (AXIN1) (Axin 1 (AXIN1))
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Bindungsspezifität
- AA 546-752
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser Axin Antikörper ist unkonjugiert
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Applikation
- ELISA
- Verwendungszweck
- AXIN1 Antibody
- Aufreinigung
- Purified antibody
- Immunogen
- Purified recombinant fragment of human 4F10G1 (AA: 546-752) expressed in E. Coli.
- Klon
- 4F10G1
- Isotyp
- IgG1
- Top Product
- Discover our top product AXIN1 Primärantikörper
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- Applikationshinweise
- ELISA: 1/10000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- Target
- Axin (AXIN1) (Axin 1 (AXIN1))
- Andere Bezeichnung
- AXIN1 (AXIN1 Produkte)
- Hintergrund
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This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants.
- Molekulargewicht
- 95.6 kDa
- Gen-ID
- 8312
- UniProt
- O15169
- Pathways
- WNT Signalweg, Sensory Perception of Sound, Regulation of G-Protein Coupled Receptor Protein Signaling
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