Adenosine A2a Receptor Antikörper (AA 274-412)

Produktnummer ABIN5611128

Der Maus Monoklonal Anti-Adenosine A2a Receptor-Antikörper wurde für ELISA, FACS und ICC validiert. Er ist geeignet, Adenosine A2a Receptor in Proben von Human zu detektieren.

Kurzübersicht für Adenosine A2a Receptor Antikörper (AA 274-412) (ABIN5611128)

Target: Adenosine A2a Receptor (ADORA2A)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Adenosine A2a Receptor Antikörper ist unkonjugiert

Applikation: ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Klon: 6A6G11

Produktdetails anti-Adenosine A2a Receptor Antikörper

Bindungsspezifität: AA 274-412

Verwendungszweck: ADORA2A Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human ADORA2A (AA: 274-412) expressed in E. Coli.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/100 - 1/500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Details zu Adenosine A2a Receptor

Target: Adenosine A2a Receptor (ADORA2A)

Andere Bezeichnung: ADORA2A

Hintergrund: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding.

Molekulargewicht: 44.7 kDa

Gen-ID: 135

UniProt: P29274

Pathways: Neurotrophin Signalübertragung, cAMP Metabolic Process, Synaptic Membrane, Feeding Behaviour, Cancer Immune Checkpoints