Adenosine A2a Receptor Antikörper

Produktnummer ABIN7258746

Produktdetails anti-Adenosine A2a Receptor Antikörper

Target: Adenosine A2a Receptor (ADORA2A)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Adenosine A2a Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: A synthetic peptide of human ADORA2A (NP_000666.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000 IF 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Adenosine A2a Receptor

Target: Adenosine A2a Receptor (ADORA2A)

Andere Bezeichnung: ADORA2A (ADORA2A Produkte)

Synonyme: ADORA2A antikoerper, adora2a.1 antikoerper, zgc:194773 antikoerper, A2aR antikoerper, ADORA2 antikoerper, RDC8 antikoerper, A2AAR antikoerper, AA2AR antikoerper, A2ar antikoerper, ADENO antikoerper, Adora2l1 antikoerper, adora2a.2 antikoerper, zgc:193802 antikoerper, zgc:193822 antikoerper, adenosine A2a receptor antikoerper, adenosine A2a receptor a antikoerper, adenosine A2a receptor L homeolog antikoerper, adenosine A2a receptor b antikoerper, ADORA2A antikoerper, Adora2a antikoerper, adora2aa antikoerper, adora2a.L antikoerper, adora2a antikoerper, adora2ab antikoerper

Hintergrund: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding.

Molekulargewicht:

Observed_MW: 45 kDa

Calculated_MW: 44 kDa

Gen-ID: 135

UniProt: P29274

Pathways: Neurotrophin Signalübertragung, cAMP Metabolic Process, Synaptic Membrane, Feeding Behaviour, Cancer Immune Checkpoints