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TET3 Antikörper (N-Term)

Der Kaninchen Polyklonal Anti-TET3-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, TET3 in Proben von Human zu detektieren.
Rockland
Produktnummer ABIN5596980
Hersteller Produkt- Nr.: 100-401-n94

Kurzübersicht für TET3 Antikörper (N-Term) (ABIN5596980)

Target

Alle TET3 Antikörper anzeigen
TET3 (Tet Methylcytosine Dioxygenase 3 (TET3))

Reaktivität

  • 22
  • 7
  • 2
Human

Wirt

  • 13
  • 10
  • 1
Kaninchen

Klonalität

  • 15
  • 9
Polyklonal

Konjugat

  • 20
  • 2
  • 1
  • 1
Dieser TET3 Antikörper ist unkonjugiert

Applikation

  • 19
  • 6
  • 5
  • 4
  • 4
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA
  • Bindungsspezifität

    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    N-Term

    Hersteller Produkt- Nr.

    100-401-n94

    Hersteller

    Rockland

    Verwendungszweck

    TET3 Antibody

    Produktmerkmale

    Synonyms: rabbit anti-TET3 Antibody, TET antibodies, Anti-TET Methylcytosine Dioxygenase 3, Anti-TET3 polyclonal antibody, KIAA0401 antibody, dioxygenase antibodies

    Aufreinigung

    Anti-TET3 Antibody was prepared from whole rabbit antiserum by delipidation and defibrination. The antiserum was further cross-absorbed against MBP by chromatography.

    Sterilität

    Sterile filtered

    Immunogen

    Immunogen: TET3 antibody was prepared from whole rabbit serum produced by repeated immunizations with a human TET-3 domain containing the N-terminal 160 amino acids of the protein.

    Immunogen Type: Recombinant Protein

  • Applikationshinweise

    Application Note: Tet3 antibody has been tested by Western Blot. Specific conditions for reactivity should be optimized by the end user. Expect band at ~180 kDa. This antibody is suitable for use by ELISA.

    Western Blot Dilution: 1:5000

    ELISA Dilution: 1:50,000

    Other: User Optimized

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    70 mg/mL

    Buffer

    Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

    Stabilizer: None

    Preservative: 0.01 % (w/v) Sodium Azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

    Haltbarkeit

    12 months
  • Target

    TET3 (Tet Methylcytosine Dioxygenase 3 (TET3))

    Andere Bezeichnung

    TET3

    Hintergrund

    Background: Anti-Tet3 is expressed in colon, muscle, adrenal gland and peripheral blood lymphocytes. Anti-Tet3 is involved in the epigenetic chromatin reprogramming of a zygote after its fertilization, and the demethylation occurs before the first cell division in the paternal pronucleus. Tet 3 antibody cannot bind to the maternal pronucleus chromatin due to DPPA3/PGC7 chromatin presence. Tet 3 functions as the dioxygenase which synthesizes a hydroxyl group to 5-methylcystosine (5mC) to form 5-hydroxymethylcystosine. Tet3 mediates the formation of 5-formylcystosine from 5hmC and subsequently 5fC to 5-carboxylcystosine, and consequently Tet3 plays an active role in catalyzing those conversions which have been suggested as the first step for cytosine DNA de-methylation. Tet 3 also recruits O-GlcNAc transferase OGT to aid H2B GlcNAcylation by OGT. Anti-TET3 antibodies are ideal for researchers interested in Epigenetics, Cancer, Chromatin Research and Histone research.

    Gen-ID

    200424

    NCBI Accession

    NP_659430

    UniProt

    O43151

    Pathways

    Warburg Effekt
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