Rekombinanter Cyclin E1 Antikörper
Kurzübersicht für Rekombinanter Cyclin E1 Antikörper (ABIN5557295)
Target
Alle Cyclin E1 (CCNE1) Antikörper anzeigenAntikörpertyp
Reaktivität
Wirt
Klonalität
Konjugat
Applikation
-
-
Verwendungszweck
- Cyclin E1 Recombinant Antibody
-
Kreuzreaktivität
- Human
-
Aufreinigung
- Purified by Protein A.
-
Immunogen
- Synthetic peptide derive from human cyclin e1
-
Isotyp
- IgG
-
-
-
-
Applikationshinweise
- WB(1:1000-5000), IHC-P(1:200-500), IHC-F(1:200-500), IF(1:200-500), ICC/IF(1:100-200)
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Liquid
-
Konzentration
- Lot specific
-
Buffer
- 0.01M TBS ( pH 7.4), 1 % BSA, 0.02 % Proclin 300, and 50 % Glycerol
-
Konservierungsmittel
- ProClin
-
Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Lagerung
- 4 °C,-20 °C
-
Informationen zur Lagerung
- Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
-
Haltbarkeit
- 12 months
-
-
- Cyclin E1 (CCNE1)
-
Andere Bezeichnung
- Cyclin E1
-
Hintergrund
-
Synonyms: Cyclin E1 phospho T77, p-Cyclin E1 phospho T77, Cyclin E1 Thr77, CCNE 1, CCNE,CCNE1,Cyclin E1 antibody Cyclin Es,Cyclin Et,CyclinE, G1/S specic cyclin E.
Background: Cyclin E is a regulatory subunit of Cdk2 and controls G1 / S transition during the mammalian cell cycle. Multiple isoforms of Cyclin E are only expressed in tumors but not in normal tissue, suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in the Cyclin E protein have been implicated as indicators of worse prognosis in various cancers.
-
Gen-ID
- 898
-
UniProt
- P24864
-
Pathways
- Zellzyklus, Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Mitotic G1-G1/S Phases
Target
-