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c-MYC Antikörper (pSer62)

This anti-c-MYC antibody (ABIN5557289) is a Rabbit Monoclonal antibody detecting c-MYC in WB, IHC (p), IF (cc). Suitable for Human, Rat.
Produktnummer ABIN5557289

Kurzübersicht für c-MYC Antikörper (pSer62) (ABIN5557289)

Target

Alle c-MYC (MYC) Antikörper anzeigen
c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Reaktivität

  • 361
  • 167
  • 117
  • 15
  • 15
  • 13
  • 13
  • 13
  • 11
  • 9
  • 9
  • 6
  • 6
  • 6
  • 5
  • 4
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Ratte

Wirt

  • 280
  • 103
  • 7
  • 5
  • 3
  • 1
  • 1
Kaninchen

Klonalität

  • 267
  • 132
Monoklonal

Konjugat

  • 205
  • 30
  • 24
  • 22
  • 8
  • 6
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser c-MYC Antikörper ist unkonjugiert

Applikation

  • 292
  • 148
  • 97
  • 88
  • 84
  • 63
  • 57
  • 31
  • 27
  • 26
  • 18
  • 14
  • 12
  • 11
  • 7
  • 4
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Klon

1A7
  • Bindungsspezifität

    • 59
    • 51
    • 47
    • 41
    • 24
    • 22
    • 17
    • 15
    • 15
    • 13
    • 11
    • 7
    • 7
    • 6
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer62

    Kreuzreaktivität

    Human, Ratte

    Aufreinigung

    Purified by Protein A.

    Immunogen

    Synthetic peptide derived from human c-Myc(S62), around 50-100aa (phospho S62).

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:300-5000
    IHC-P 1:200-400
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    Haltbarkeit

    12 months
  • Target

    c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

    Andere Bezeichnung

    c-Myc

    Hintergrund

    Synonyms: Avian myelocytomatosis viral oncogene homolog, bHLHe39, c Myc, c Myc Epitope Tag, c Myc Tag, Cellular myelocytomatosis oncogene, MGC105490, MRTL, Myc Epitope Tag, Myc protein, Myc proto oncogene protein, Myc proto-oncogene protein, Myc-related translation/localization regulatory factor, Myc2, myca, Myelocytomatosis oncogene a, Myelocytomatosis oncogene, Niard, Nird, Oncogene Myc, Protooncogene homologous to myelocytomatosis virus, RNCMYC, Transcription factor p64, Transcriptional regulator Myc-A, V-Myc avian myelocytomatosis viral oncogene homolog, v-myc myelocytomatosis viral oncogene homolog avian, zc-myc.

    Background: Epitope tags are useful for the labeling and detection of proteins usingimmunoblotting, immunoprecipitation and immunostaining techniques. Due to their small size, they are unlikely to affect the tagged protein's biochemical properties. The Myc epitope tag is widely used to detect expression of recombinant proteins in bacteria, yeast,insect and mammalian cell systems.The c-Myc protein is a transcription factor, which is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies also have shown that c-Myc is essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells, and which brought extensive attention in the development of new therapeutic approach for cancer treatment.

    Gen-ID

    4609

    UniProt

    P01106

    Pathways

    p53 Signalweg, Zellzyklus, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Warburg Effekt
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