p130 Antikörper (AA 939-1139)
Kurzübersicht für p130 Antikörper (AA 939-1139) (ABIN5542553)
Target
Alle p130 (RBL2) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Bindungsspezifität
- AA 939-1139
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Verwendungszweck
- RBL2 Antibody
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Aufreinigung
- Purified antibody
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Immunogen
- Purified recombinant fragment of human RBL2 (AA: 939-1139) expressed in E. Coli.
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Isotyp
- IgG1
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anti-Retinoblastoma-Like 2 (p130) (RBL2) (AA 165-194), (N-Term) antibody
RBL2 Reaktivität: Human WB, FACS Wirt: Kaninchen Polyclonal RB31021 unconjugated
anti-Retinoblastoma-Like 2 (p130) (RBL2) (AA 26-367) antibodyRBL2 Reaktivität: Human, Ratte, Maus, Blow Fly, Huhn WB, IF, IHC, IP Wirt: Maus Monoclonal 10-Rb2 unconjugated
anti-Retinoblastoma-Like 2 (p130) (RBL2) (AA 100-200) antibodyRBL2 Reaktivität: Human WB, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Retinoblastoma-Like 2 (p130) (RBL2) antibodyRBL2 Reaktivität: Ratte, Maus IF, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Retinoblastoma-Like 2 (p130) (RBL2) (AA 417-616) antibodyRBL2 Reaktivität: Human ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Retinoblastoma-Like 2 (p130) (RBL2) antibodyRBL2 Reaktivität: Human, Ratte, Maus ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Retinoblastoma-Like 2 (p130) (RBL2) antibodyRBL2 Reaktivität: Human, Ratte, Maus WB Wirt: Kaninchen Polyclonal unconjugated
anti-Retinoblastoma-Like 2 (p130) (RBL2) (AA 416-515) antibodyRBL2 Reaktivität: Human WB, ELISA Wirt: Maus Polyclonal unconjugated
anti-Retinoblastoma-Like 2 (p130) (RBL2) (AA 175-189) antibodyRBL2 Reaktivität: Human WB, IHC, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Retinoblastoma-Like 2 (p130) (RBL2) (AA 416-515) antibodyRBL2 Reaktivität: Human ELISA Wirt: Maus Monoclonal 4D7 unconjugated
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Applikationshinweise
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ELISA: 1/10000
FCM: 1/200 - 1/400
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- Purified antibody in PBS with 0.05 % sodium azide.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))
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Andere Bezeichnung
- RBL2
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Hintergrund
- RBL2 is a Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
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Molekulargewicht
- 128.4 kDa
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Gen-ID
- 5934
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UniProt
- Q08999
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Pathways
- Zellzyklus, Mitotic G1-G1/S Phases
Target
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