ACTH Antikörper (AA 1-24)

Produktnummer ABIN5542231

Dieses Anti-ACTH-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von ACTH in IHC (p) und EIA. Geeignet für Human und Ratte.

Kurzübersicht für ACTH Antikörper (AA 1-24) (ABIN5542231)

Target: ACTH (Adrenocorticotropic hormone (ACTH))

Reaktivität: Human, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ACTH Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Klon: 57 (BGN-1388-66)

Produktdetails anti-ACTH Antikörper

Bindungsspezifität: AA 1-24

Sequenz: SYSMEHFRWG KPVGKKRRPV KVYP

Spezifität: This antibody recognizes 1-24 ACTH (Synacthen) which, as a synthetic analogue of naturally-occurring Adrenocorticotropic Hormone, can be used to measure adrenal reserve and for the diagnosis of adrenal insufficiency by acute adrenocortical stimulation. It does not recognize 17-39 ACTH (CLIP). Species: Human. Cross-reacts with Rat N-terminal ACTH.

Aufreinigung: Affinity Chromatography on Protein A

Immunogen: Synthetic peptide corresponding to the amino acids 1-24 of the Human ACTH conjugated to Keyhole Limpet Haemocyanin.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA. Immunohistochemistry on Formalin Fixed Paraffin Embedded Sections: 1/100-1/200 (Requires protein digestion pre-treatment of paraffin sections e.g. trypsin or pronase).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, pH 7.2 Preservatives: 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu ACTH

Target: ACTH (Adrenocorticotropic hormone (ACTH))

Substanzklasse: Hormone

Hintergrund: ACTH, released from the anterior pituitary gland in response to corticotropin-releasing hormone from the hypothalamus, acts on the adrenal cortex to stimulate the production of corticosteroids such as cortisol, involved in the response to stress. Studies have shown that the administration of 1-24 ACTH increases blood pressure, believed to be attributed to an increase in ACTH-stimulated cortisol secretion, in association with increased cardiac output.

Pathways: Metabolism of Steroid Hormones and Vitamin D, Peptide Hormone Metabolism, Hormone Activity