ACTH Antikörper

Produktnummer ABIN7193645

Produktdetails anti-ACTH Antikörper

Target: ACTH (Adrenocorticotropic hormone (ACTH))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ACTH Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), ELISA, Western Blotting (WB), Immunocytochemistry (ICC)

Aufreinigung: purified

Immunogen: Purified recombinant fragment of human ACTH expressed in E. coli.

Klon: 3A4H4

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB:1:500 - 1:2000, ICC:1:200 - 1:1000, FCM:1:200 - 1:400, ELISA:1:10000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: 4°C, -20°C for long term storage

Details zu ACTH

Target: ACTH (Adrenocorticotropic hormone (ACTH))

Andere Bezeichnung: ACTH (ACTH Produkte)

Synonyme: ACTH antikoerper, BE antikoerper, Beta-LPH antikoerper, Clip antikoerper, Gamma-LPH antikoerper, Npp antikoerper, Pomc-1 antikoerper, Pomc1 antikoerper, alpha-MSH antikoerper, alphaMSH antikoerper, beta-MSH antikoerper, gamma-MSH antikoerper, CLIP antikoerper, LPH antikoerper, MSH antikoerper, NPP antikoerper, POC antikoerper, pro-opiomelanocortin-alpha antikoerper, proopiomelanocortin antikoerper, Pomc antikoerper, POMC antikoerper

Hintergrund:

Description: This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used, adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.

Aliases: POMC, LPH, MSH, NPP, POC, CLIP

Molekulargewicht: 29.4 kDa

Gen-ID: 5443

Pathways: Metabolism of Steroid Hormones and Vitamin D, Peptide Hormone Metabolism, Hormone Activity