CD46 Antikörper

Produktnummer ABIN5541990

Der Maus Monoklonal Anti-CD46-Antikörper wurde für WB, IF, ICC, IHC (fro) und EIA validiert. Er ist geeignet, CD46 in Proben von Ratte zu detektieren.

Kurzübersicht für CD46 Antikörper (ABIN5541990)

Target: CD46

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD46 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Klon: MM-1

Produktdetails anti-CD46 Antikörper

Spezifität: The monoclonal antibody MM.1 recognizes CD46, also known as membrane cofactor protein.

Aufreinigung: Purified

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western blot: Rat testis lysate, non-reducing conditions, band size 38 kDa (Ref.1,4). Immuno Assays (Ref.1). Immunofluorescence (Ref.2-4). Immunohistochemistry on Frozen Sections (Ref.1-3). The typical starting working dilution is 1/50.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Buffer System: PBS Stabilizers: 0.1 % BSA

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu CD46

Target: CD46

Andere Bezeichnung: cd46,mcp

Hintergrund: An immunohistological survey of rat tissues revealed that CD46 is expressed only in the testis and epididymis of adult rats more specifically, only by spermatozoa and late spermatozoal precursors. In contrast, in humans, CD46 is expressed on every cell and tissue, with the exception of erythrocytes. CD46 serves to down-regulate the activation of complement on host tissue. It functions as a cofactor by binding to C3b and C4b. Binding is permitted by factor I, a serine protease of plasma, to degrade C3b and C4b and serves to protect the host cell against autologous attack. In human, it also serves as a receptor for measles virus. Two isoforms of CD46 predominate and arise by alternative splicing of a single CD46 gene. The isoforms differ in the length. CD46 cDNA encodes a signal sequence followed by four complement control protein domains (also called short consensus repeats (SCR)).

UniProt: Q9Z0M4

Pathways: Regulation of Actin Filament Polymerization