MAPT Antikörper (pSer202)

Produktnummer ABIN5541354

Der Kaninchen Polyklonal anti-MAPT Antikörper wird verwendet zum Nachweis von MAPT in Proben von Human, Ratte und Maus. Er wurde validiert für WB.

Kurzübersicht für MAPT Antikörper (pSer202) (ABIN5541354)

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAPT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MAPT Antikörper

Bindungsspezifität: pSer202

Spezifität: The antibody detects endogenous levels of Tau only when phosphorylated at serine 202.

Aufreinigung: Affinity chromatography using epitope-specific peptide

Immunogen: Peptide sequence around phosphorylation site of serine 202(P-G-S(p)-P-G) derived from Human Tau (KLH-conjugated)

Anwendungsinformationen

Applikationshinweise: Western blot: 1:500~1:1000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu MAPT

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Andere Bezeichnung: mapt,tau

Hintergrund: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

UniProt: P10636

Pathways: MAPK Signalweg, Microtubule Dynamics, M Phase, Regulation of Cell Size