alpha 2 Macroglobulin Antikörper

Produktnummer ABIN5541044

Dieser Maus Monoklonal Antikörper detektiert spezifisch alpha 2 Macroglobulin in EIA und RIA. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für alpha 2 Macroglobulin Antikörper (ABIN5541044)

Target: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser alpha 2 Macroglobulin Antikörper ist unkonjugiert

Applikation: Enzyme Immunoassay (EIA), Radioimmunoassay (RIA)

Klon: 2N1-10

Produktdetails anti-alpha 2 Macroglobulin Antikörper

Spezifität: This antibody recognises alpha 2-macroglobulin, a tetrameric glycoprotein of 720 kDa which functions as a proteinase inhibitor. Species: Human.

Aufreinigung: DEAE-chromatography

Immunogen: Purified alpha-2 macroglobulin from human plasma.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA. Radioimmunoassays

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.09 % Sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu alpha 2 Macroglobulin

Target: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Andere Bezeichnung: alpha-2-macroglobulin,a2m

Hintergrund: Alpha 2 macroglobulin is a serum protein which is mainly synthesised in the liver. It functions as a broad range irreversible proteinase inhibitor that forms a trap around most proteases. Alpha 2 macroglobulin is a tetrameric molecule, and with a molecular weight of 720 kDa, it so large a molecule that it tends to remain intravascular. Following conformational change the proteinase is deposited within a central cavity where it is still active but prevented from further contact with its substrate. Removal of the complex is mediated by the generation of recognition sites which react with receptors on a variety of cells including macrophages and liver cells. Alpha 2 macroglobulin is localized on the surface of peripheral blood lymphocytes.

UniProt: P01023

Pathways: Lipid Metabolism