ING2 Antikörper (AA 1-280)

Produktnummer ABIN5540825

Dieses Maus Monoklonal-Antikörper erkennt spezifisch ING2 in WB und EIA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für ING2 Antikörper (AA 1-280) (ABIN5540825)

Target: ING2 (Inhibitor of Growth Family, Member 2 (ING2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ING2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Klon: AT39E5

Produktdetails anti-ING2 Antikörper

Bindungsspezifität: AA 1-280

Aufreinigung: Protein-A affinity chromatography

Immunogen: Recombinant human ING2 (1-280aa) purified from E. coli

Anwendungsinformationen

Applikationshinweise: The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:1000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, pH 7.4 containing 0.02 % Sodium Azide and 10 % Glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu ING2

Target: ING2 (Inhibitor of Growth Family, Member 2 (ING2))

Andere Bezeichnung: ing2,ing1l

Hintergrund: ING2 is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. This protein seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Also, It is component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides.

UniProt: Q9H160

Pathways: Chromatin Binding, Autophagie, Negative Regulation of intrinsic apoptotic Signaling