CD40 Ligand Antikörper

Produktnummer ABIN5540106

Der Maus Monoklonal anti-CD40 Ligand Antikörper wird verwendet zum Nachweis von CD40 Ligand in Proben von Human und Primate. Er wurde validiert für FACS, ICC, IF und Func.

Kurzübersicht für CD40 Ligand Antikörper (ABIN5540106)

Target: CD40 Ligand (CD40LG)

Reaktivität: Human, Primate

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD40 Ligand Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Functional Studies (Func)

Klon: 24-31

Produktdetails anti-CD40 Ligand Antikörper

Spezifität: This antibody detects CD154 / CD40L (CD40-ligand), a 39 kDa cell surface type II glycoprotein expressed predominantly on activated CD4+ lymphocytes.

Aufreinigung: Protein-A affinity chromatography (> 95% pure by SDS-PAGE)

Immunogen: Human CD154 fusion protein

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow cytometry. Immunocytochemistry. Functional application: blocking.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 95 % pure by SDS-PAGE) Buffer System: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu CD40 Ligand

Target: CD40 Ligand (CD40LG)

Andere Bezeichnung: cd154,cd40l

Hintergrund: CD154 / CD40L (CD40 ligand) is a member of the tumor necrosis factor family, and is expressed primarily on activated CD4+ lymphocytes, but also on mast cells, basophils, eosinophils and human dendritic cells. Its counter-receptor CD40 is expressed on antigen presenting cells, including dendritic cells, macrophages, and B cells, and also on fibroblasts. Triggering of CD40 by CD40L causes maturation of dendritic cells and upregulation of antigen presentation in functions of the MHC and costimulatory molecules. CD40L also functions as a direct stimulating factor for T cells. CD40L plays also roles e.g. in antibody class switching and modulation of apoptosis in the germinal center.

UniProt: P29965

Pathways: NF-kappaB Signalweg, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints