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LIN28B Antikörper (AA 95-128)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch LIN28B in WB, FACS, IF und IHC (p). Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN5536364

Kurzübersicht für LIN28B Antikörper (AA 95-128) (ABIN5536364)

Target

Alle LIN28B Antikörper anzeigen
LIN28B (Lin-28 Homolog B (LIN28B))

Reaktivität

  • 48
  • 9
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 47
  • 1
  • 1
Kaninchen

Klonalität

  • 46
  • 3
Polyklonal

Konjugat

  • 33
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser LIN28B Antikörper ist unkonjugiert

Applikation

  • 33
  • 21
  • 21
  • 20
  • 17
  • 6
  • 5
  • 4
  • 4
  • 1
Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • Bindungsspezifität

    • 8
    • 6
    • 6
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 95-128

    Aufreinigung

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    Immunogen

    This LIN28B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-128 amino acids from the Central region of human LIN28B.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    For IHC-P starting dilution is: 1:25

    For WB starting dilution is: 1:1000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    0.33 mg/mL

    Buffer

    Supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target

    LIN28B (Lin-28 Homolog B (LIN28B))

    Andere Bezeichnung

    LIN28B

    Hintergrund

    Lin-28 homolog B (LIN28B) is overexpressed in hepatocellular carcinoma. The heterochronic gene lin-28 is a key regulator of developmental timing in the nematode Caenorhabditis elegans. Similar with lin-28 proteins, LIN28B conserves a cold shock domain and a pair of CCHC zinc finger domains. Phylogenetic analysis suggests that they might arise as a result of duplication from an ancestral gene. Overexpression of LIN28B was noted in most HCC cell lines and clinical samples. A short LIN28B isoform was also identified in non-tumor liver tissue and fetal liver. Although predominantly localized in the cytoplasm, LIN28B protein shows cell cycle-dependent nuclear translocation in Huh7 cells. Induced expression of exogenous LIN28B in a tet-off cell line promoted cancer cell proliferation.

    Molekulargewicht

    27 kDa

    Gen-ID

    389421

    UniProt

    Q6ZN17
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