IGF1R Antikörper (AA 31-257)
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- Target Alle IGF1R Antikörper anzeigen
- IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))
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Bindungsspezifität
- AA 31-257
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Reaktivität
- Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser IGF1R Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Verwendungszweck
- Rabbit IgG polyclonal antibody for IGF1 Receptor detection. Tested with WB, IHC-P, Direct ELISA in Mouse,Rat.
- Kreuzreaktivität (Details)
- No cross reactivity with other proteins.
- Produktmerkmale
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Rabbit IgG polyclonal antibody for IGF1 Receptor detection. Tested with WB, IHC-P, Direct ELISA in Mouse,Rat.
Gene Name: insulin-like growth factor I receptor
Protein Name: Insulin-like growth factor 1 receptor - Aufreinigung
- Immunogen affinity purified.
- Immunogen
- E. coli-derived mouse IGF1 Receptor recombinant protein (Position: E31-K257).
- Isotyp
- IgG
- Top Product
- Discover our top product IGF1R Primärantikörper
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- Applikationshinweise
- Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
- Kommentare
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Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- Konzentration
- 500 μg/mL
- Buffer
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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Long-pulse gastric electrical stimulation protects interstitial cells of Cajal in diabetic rats via IGF-1 signaling pathway." in: World journal of gastroenterology, Vol. 22, Issue 23, pp. 5353-63, (2017) (PubMed).
: "Let-7a inhibits migration of melanoma cells via down-regulation of HMGA2 expression." in: American journal of translational research, Vol. 8, Issue 9, pp. 3656-3665, (2016) (PubMed).
: "Insulin-like growth factors in endometrioid adenocarcinoma: correlation with clinico-pathological features and estrogen receptor expression." in: BMC cancer, Vol. 12, pp. 262, (2013) (PubMed).
: "Treating human meniscal fibrochondrocytes with hIGF-1 gene by liposome." in: Clinical orthopaedics and related research, Vol. 467, Issue 12, pp. 3175-82, (2010) (PubMed).
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Long-pulse gastric electrical stimulation protects interstitial cells of Cajal in diabetic rats via IGF-1 signaling pathway." in: World journal of gastroenterology, Vol. 22, Issue 23, pp. 5353-63, (2017) (PubMed).
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- Target
- IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))
- Andere Bezeichnung
- IGF1R (IGF1R Produkte)
- Synonyme
- CMT2N antikoerper, CD221 antikoerper, IGFIR antikoerper, IGFR antikoerper, JTK13 antikoerper, IGFIRC antikoerper, IGFR1 antikoerper, IGF-1R antikoerper, IGF1R antikoerper, DKFZp469I0618 antikoerper, igf-1r antikoerper, xIGF-1R antikoerper, xIGFR antikoerper, xigf1r antikoerper, A330103N21Rik antikoerper, D930020L01 antikoerper, hyft antikoerper, igf-ir antikoerper, IGF-IR antikoerper, IGF-IRb antikoerper, wu:fb03h06 antikoerper, IGF-IRa antikoerper, sb:eu1090 antikoerper, wu:fi20b10 antikoerper, alanyl-tRNA synthetase antikoerper, insulin like growth factor 1 receptor antikoerper, insulin-like growth factor 1 receptor antikoerper, insulin-like growth factor 1 antikoerper, insulin-like growth factor I receptor antikoerper, insulin like growth factor 1 receptor S homeolog antikoerper, insulin-like growth factor 1b receptor antikoerper, insulin-like growth factor 1a receptor antikoerper, AARS antikoerper, IGF1R antikoerper, Igf1r antikoerper, igf1r antikoerper, Igf1 antikoerper, LOC780503 antikoerper, LOC100136427 antikoerper, igf1r.S antikoerper, igf1rb antikoerper, igf1ra antikoerper
- Hintergrund
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IGF1R(Insulin-like Growth Factor 1 (IGF-1) Receptor) is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called Insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors. The IGF1R gene is mapped on 15q26.3. IGF-1 plays an important role in growth and continues to have anabolic effects in adults - meaning that it can induce hypertrophy of skeletal muscle and other target tissues. Using a yeast 2-hybrid system, it was identified a regulatory subunit of phosphatidylinositol (PI) 3-kinase, PIK3R3, as a binding partner of IGF1R. Functional interaction between BRCA1 and SP1 in the regulation of the IGF1R gene was studied in Schneider cells, a Drosophila cell line which lacks endogenous SP1. In these cells, BRCA1 suppressed 45 % of the SP1-induced trans-activation of the IGF1R promoter. Overexpression of the Grb10-binding fragment of Gigyf1 resulted in a significant increase in Igf1-stimulated Igf1r tyrosine phosphorylation. Like the insulin receptor, the IGF-1 receptor is a receptor tyrosine kinase - meaning it signals by causing the addition of a phosphate molecule on particular tyrosines. IGF-1 activates the Insulin receptor at approximately 0.1x the potency of insulin. Part of this signaling may be via IGF1R-InsulinReceptor heterodimers.
Synonyms: Insulin-like growth factor 1 receptor, Insulin-like growth factor I receptor, IGF-I receptor, CD221, Insulin-like growth factor 1 receptor alpha chain, Insulin-like growth factor 1 receptor beta chain, Igf1r - Gen-ID
- 16001
- UniProt
- Q60751
- Pathways
- RTK Signalweg, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagie
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