ADAM17 Antikörper (AA 215-433)
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- Target Alle ADAM17 Antikörper anzeigen
- ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))
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Bindungsspezifität
- AA 215-433
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Reaktivität
- Human, Ratte, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser ADAM17 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA
- Verwendungszweck
- Rabbit IgG polyclonal antibody for ADAM17 detection. Tested with WB, Direct ELISA in Human,Mouse,Rat.
- Kreuzreaktivität (Details)
- No cross reactivity with other proteins.
- Produktmerkmale
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Rabbit IgG polyclonal antibody for ADAM17 detection. Tested with WB, Direct ELISA in Human,Mouse,Rat.
Gene Name: ADAM metallopeptidase domain 17
Protein Name: Disintegrin and metalloproteinase domain-containing protein 17 - Aufreinigung
- Immunogen affinity purified.
- Immunogen
- E. coli-derived human ADAM17 recombinant protein (Position: R215-Y433).
- Isotyp
- IgG
- Top Product
- Discover our top product ADAM17 Primärantikörper
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- Applikationshinweise
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Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users. - Kommentare
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Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- Konzentration
- 500 μg/mL
- Buffer
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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- Target
- ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))
- Andere Bezeichnung
- ADAM17 (ADAM17 Produkte)
- Synonyme
- ADAM18 antikoerper, CD156B antikoerper, CSVP antikoerper, NISBD antikoerper, TACE antikoerper, CD156b antikoerper, Tace antikoerper, adam17 antikoerper, si:dkey-81b15.2 antikoerper, adam18 antikoerper, cd156b antikoerper, csvp antikoerper, tace antikoerper, fc20b01 antikoerper, wu:fc20b01 antikoerper, zgc:63886 antikoerper, ADAM metallopeptidase domain 17 antikoerper, a disintegrin and metallopeptidase domain 17 antikoerper, ADAM metallopeptidase domain 17b antikoerper, ADAM metallopeptidase domain 17 L homeolog antikoerper, ADAM metallopeptidase domain 17a antikoerper, ADAM17 antikoerper, Adam17 antikoerper, adam17b antikoerper, adam17.L antikoerper, adam17a antikoerper
- Hintergrund
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ADAM17(ADAM metallopeptidase domain 17), also called TACE (tumor necrosis factor-α-converting enzyme), is a 70- kDa enzyme that belongs to the ADAM protein family of disintegrins and metalloproteases. Expression studies showed that the encoded protein cleaves precursor tumor necrosis factor-alpha to its mature form. Northern blot analysis revealed that the gene was expressed as a 5-kb mRNA in all tissues examined. ADAM17 is understood to be involved in the processing of tumor necrosis factor alpha (TNF-α) at the surface of the cell, and from within theintracellular membranes of the trans-Golgi network. This process, which is also known as 'shedding', involves the cleavage and release of a soluble ectodomain from membrane-bound pro-proteins (such as pro-TNF-α), and is of known physiological importance. ADAM17 was the first 'sheddase' to be identified, and is also understood to play a role in the release of a diverse variety of membrane-anchored cytokines, cell adhesion molecules,receptors, ligands, and enzymes.
Synonyms: Disintegrin and metalloproteinase domain-containing protein 17, ADAM 17, Snake venom-like protease, TNF-alpha convertase, TNF-alpha-converting enzyme, CD156b, ADAM17, CSVP, TACE - Gen-ID
- 6868
- UniProt
- P78536
- Pathways
- Notch Signalweg, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Response to Growth Hormone Stimulus
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