RASA1 Antikörper (N-Term)

Produktnummer ABIN5516840

Dieses Anti-RASA1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von RASA1 in WB. Geeignet für Human.

Kurzübersicht für RASA1 Antikörper (N-Term) (ABIN5516840)

Target: RASA1 (RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RASA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-RASA1 Antikörper

Bindungsspezifität: N-Term

Sequenz: GTVDEGDSLD GPEYEEEEVA IPLTAPPTNQ WYHGKLDRTI AEERLRQAGK

Produktmerkmale: This is a rabbit polyclonal antibody against RASA1. It was validated on Western Blot.

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human RASA1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu RASA1

Target: RASA1 (RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1))

Andere Bezeichnung: RASA1

Hintergrund: The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues.

Alias Symbols: RASA1, GAP, RASA,

Protein Interaction Partner: ARHGAP35, DOK1, KHDRBS1, DOK2, PLCG1, EGFR, ABL1, Mbp, ERBB4, ERBB3, ERBB2, APP, SOCS1, UBC, SPSB1, ZNF579, BBS10, TRMT2A, EIF1, SERPINA4, XRCC6, EZH2, NCK1, BTRC, NFKBIA, DOK4, AFAP1L2, DNAJA3, G3BP1, PAG1, AURKB, MAP4K4, SOCS3, BIRC5, ARHGAP1, ARHGAP5,

Protein Size: 1047

Gen-ID: 5921

UniProt: P20936

Pathways: Regulation of Actin Filament Polymerization, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals