CD70 Antikörper (C-Term)

Produktnummer ABIN5516679

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch CD70 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Rind (Kuh), Kaninchen, Pferd, Schwein und Hund.

Kurzübersicht für CD70 Antikörper (C-Term) (ABIN5516679)

Target: CD70 (CD70 Molecule (CD70))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Kaninchen, Pferd, Schwein, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD70 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CD70 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: CD70 Antibody - C-terminal region

Sequenz: RLSFHQGCTI ASQRLTPLAR GDTLCTNLTG TLLPSRNTDE TFFGVQWVRP

Homologie: Cow: 86%, Dog: 86%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 92%, Rabbit: 79%, Rat: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against CD70. It was validated on Western Blot.

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human CD70

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP61308-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu CD70

Target: CD70 (CD70 Molecule (CD70))

Andere Bezeichnung: CD70

Hintergrund:

Background Information: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.

Gene Name: CD70 Molecule

Alternative Symbols: CD27L, LPFS3, CD27-L, CD27LG, TNFSF7, TNLG8A

Protein Name: CD70 antigen

Molekulargewicht: 21 kDa

Gen-ID: 970

NCBI Accession: NP_001243

UniProt: P32970

Pathways: Cancer Immune Checkpoints