PTAFR Antikörper (N-Term)

Produktnummer ABIN5515515

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PTAFR in WB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für PTAFR Antikörper (N-Term) (ABIN5515515)

Target: PTAFR (Platelet-Activating Factor Receptor (PTAFR))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTAFR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PTAFR Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: PTAFR Antibody - N-terminal region

Sequenz: EPHDSSHMDS EFRYTLFPIV YSIIFVLGVI ANGYVLWVFA RLYPCKKFNE

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PTAFR

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP76511-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu PTAFR

Target: PTAFR (Platelet-Activating Factor Receptor (PTAFR))

Andere Bezeichnung: PTAFR

Hintergrund:

Background Information: This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants.

Gene Name: Platelet-activating factor receptor

Alternative Symbols: PAFR

Protein Name: platelet-activating factor receptor

Molekulargewicht: 39 kDa

Gen-ID: 5724

NCBI Accession: NP_000943

UniProt: P25105

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin