RAD51 Antikörper (N-Term)

Produktnummer ABIN5515419

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch RAD51 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen und Hund.

Kurzübersicht für RAD51 Antikörper (N-Term) (ABIN5515419)

Target: RAD51 (DNA Repair Protein Homolog 1 (RAD51))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAD51 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-RAD51 Antikörper

Bindungsspezifität: N-Term

Sequenz: QLEANADTSV EEESFGPQPI SRLEQCGINA NDVKKLEEAG FHTVEAVAYA

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 94%, Human: 100%, Mouse: 100%, Rabbit: 94%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against RAD51. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human RAD51

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu RAD51

Target: RAD51 (DNA Repair Protein Homolog 1 (RAD51))

Andere Bezeichnung: RAD51

Hintergrund: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene.

Alias Symbols: Name=RAD51,

Protein Interaction Partner: BRCA1, ATRX, FBXO18, PALB2, HNRNPC, SWSAP1, HNRNPA2B1, RPA3, RPA1, RAD52, PFN1, RAD54B, AICDA, BLM, DMC1, NXF1, RECQL5, UGDH, CHEK1, BRCA2, SFR1, SWI5, NEDD8, PML, TERF2IP, TP53, MSH2, MSH6, UBC, UHRF2, RAD51AP1, WRN, POLN, MORF4L1, MDC1, RAD51C, MCPH1, S

Protein Size: 339

Gen-ID: 5888

UniProt: Q06609

Pathways: DNA Reparatur