PFKFB3 Antikörper (C-Term)

Produktnummer ABIN5514397

Der Kaninchen Polyklonal anti-PFKFB3 Antikörper wird verwendet zum Nachweis von PFKFB3 in Proben von Human, Ratte, Maus, Meerschweinchen, Rind (Kuh), Pferd, Kaninchen und Hund. Er wurde validiert für WB.

Kurzübersicht für PFKFB3 Antikörper (C-Term) (ABIN5514397)

Target: PFKFB3 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3))

Reaktivität: Human, Ratte, Maus, Meerschweinchen, Rind (Kuh), Pferd, Kaninchen, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PFKFB3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PFKFB3 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: PFKFB3 Antibody - C-terminal region

Sequenz: VESVCTHRER SEDAKKGPNP LMRRNSVTPL ASPEPTKKPR INSFEEHVAS

Homologie: Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against F263. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human F263

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP56582-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu PFKFB3

Target: PFKFB3 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3))

Andere Bezeichnung: PFKFB3

Hintergrund:

Background Information: The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

Alternative Symbols: PFK2, IPFK2, iPFK-2

Protein Name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

Molekulargewicht: 57kDa

Gen-ID: 5209

UniProt: Q16875

Pathways: AMPK Signaling, Regulation of Carbohydrate Metabolic Process