PFKFB3 Antikörper (AA 400-500)
Kurzübersicht für PFKFB3 Antikörper (AA 400-500) (ABIN6145485)
Target
Alle PFKFB3 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
-
-
Bindungsspezifität
- AA 400-500
-
Sequenz
- LDKSAEEMPY LKCPLHTVLK LTPVAYGCRV ESIYLNVESV CTHRERSEDA KKGPNPLMRR NSVTPLASPE PTKKPRINSF EEHVASTSAA LPSCLPPEVP T
-
Kreuzreaktivität
- Human, Maus, Ratte
-
Produktmerkmale
- Polyclonal Antibodies
-
Immunogen
- A synthetic peptide corresponding to a sequence within amino acids 400-500 of human PFKFB3 (NP_004557.1).
-
Isotyp
- IgG
-
-
-
-
Applikationshinweise
- WB,1:500 - 1:1000,IHC,1:50 - 1:100
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Liquid
-
Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
-
Konservierungsmittel
- Sodium azide
-
Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Lagerung
- -20 °C
-
Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
-
-
- PFKFB3 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3))
-
Andere Bezeichnung
- PFKFB3
-
Hintergrund
- The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.,PFKFB3,IPFK2,PFK2,iPFK-2,Endocrine & Metabolism,Carbohydrate metabolism,AMPK Signaling Pathway,Warburg Effect,PFKFB3
-
Molekulargewicht
- 57 kDa/58 kDa/59 kDa/60 kDa
-
Gen-ID
- 5209
-
UniProt
- Q16875
-
Pathways
- AMPK Signaling, Regulation of Carbohydrate Metabolic Process
Target
-