PFKFB3 Antikörper (AA 400-500)

Produktnummer ABIN6145485

Produktdetails anti-PFKFB3 Antikörper

Target: PFKFB3 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3))

Bindungsspezifität: AA 400-500

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PFKFB3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: LDKSAEEMPY LKCPLHTVLK LTPVAYGCRV ESIYLNVESV CTHRERSEDA KKGPNPLMRR NSVTPLASPE PTKKPRINSF EEHVASTSAA LPSCLPPEVP T

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 400-500 of human PFKFB3 (NP_004557.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:1000,IHC,1:50 - 1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu PFKFB3

Target: PFKFB3 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3))

Andere Bezeichnung: PFKFB3 (PFKFB3 Produkte)

Synonyme: IPFK2 antikoerper, PFK2 antikoerper, E330010H22Rik antikoerper, iPFK-2 antikoerper, uPFK-2 antikoerper, PFKFB3 antikoerper, zgc:73257 antikoerper, wu:fc31e01 antikoerper, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 antikoerper, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 S homeolog antikoerper, PFKFB3 antikoerper, Pfkfb3 antikoerper, pfkfb3.S antikoerper, pfkfb3 antikoerper, PTRG_09894 antikoerper, Tsp_06710 antikoerper

Hintergrund: The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.,PFKFB3,IPFK2,PFK2,iPFK-2,Endocrine & Metabolism,Carbohydrate metabolism,AMPK Signaling Pathway,Warburg Effect,PFKFB3

Molekulargewicht: 57 kDa/58 kDa/59 kDa/60 kDa

Gen-ID: 5209

UniProt: Q16875

Pathways: AMPK Signaling, Regulation of Carbohydrate Metabolic Process