PFKFB3 Antikörper (pSer467)

Produktnummer ABIN744728

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-PFKFB3 Antikörper wird verwendet zum Nachweis von PFKFB3 in Proben von Human. Er wurde validiert für WB, IF (cc), IF (p), IHC (p) und IHC (fro).

Kurzübersicht für PFKFB3 Antikörper (pSer467) (ABIN744728)

Target: PFKFB3 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PFKFB3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-PFKFB3 Antikörper

Bindungsspezifität: pSer467

Verwendungszweck: Phospho-PFKFB3/PFK2 (Ser467) Polyclonal Antibody

Spezifität: This phosphorylated site is homologous to that of Ser467 in Mouse and Ser496 in Rat.

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Cow,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human PFK2 around the phosphorylation site of Ser467

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB(1:300-5000),

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-PFKFB3 Antikörper (ABIN744728)

Fu, Shi, Westaway, Jhamandas: "Bioenergetic mechanisms in astrocytes may contribute to amyloid plaque deposition and toxicity." in: The Journal of biological chemistry, Vol. 290, Issue 20, pp. 12504-13, (2015) (PubMed).

Details zu PFKFB3

Target: PFKFB3 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3))

Andere Bezeichnung: PFK2

Hintergrund:

Synonyms: PFK2, IPFK2, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, 6PF-2-K/Fru-2,6-P2ase 3, PFK/FBPase 3, 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme, Renal carcinoma antigen NY-REN-56, iPFK-2, PFKFB3

Background: 6 Phosphofructo 2 Kinase plays a role in the synthesis and degradation of fructose 2,6-bisphosphate. Fructose-2,6-bisphosphate acts as an allosteric regulator of 6-phosphofructo-1-kinase (PFK1), which catalyses a key step in the glycoytic pathway. Glycolytic flux is key to tumour growth, and small molecule inhibition of 6 Phosphofructo 2 Kinase suppresses both glycolytic flux and tumour growth. Several lines of evidence suggest that 6 Phosphofructo 2 Kinase is also involved in obesity.

Gen-ID: 5209

UniProt: Q16875

Pathways: AMPK Signaling, Regulation of Carbohydrate Metabolic Process