LDLR Antikörper (AA 500-550)

Produktnummer ABIN504726

Dieses Anti-LDLR-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von LDLR in WB und IHC. Geeignet für Human und Maus.

Kurzübersicht für LDLR Antikörper (AA 500-550) (ABIN504726)

Target: LDLR (Low Density Lipoprotein Receptor (LDLR))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LDLR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-LDLR Antikörper

Bindungsspezifität: AA 500-550

Kreuzreaktivität: Human, Maus, Primate

Aufreinigung: affinity purified

Immunogen: Synthetic peptide made to an internal portion of the human protein (within AA 500-550). [Swiss-Prot# P01130]

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Lagerung: -20 °C

Details zu LDLR

Target: LDLR (Low Density Lipoprotein Receptor (LDLR))

Andere Bezeichnung: LDL Receptor

Hintergrund: The low density lipoprotein (LDL) receptor system coordinates the metabolism of cholesterol, an essential component of the plasma membrane of all mammalian cells. Study of this system has led to an enhanced understanding of the cellular basis of cholesterol homeostasis. It has also brought into focus an important mechanism of metabolic regulation--the process of receptor-mediated endocytosis (1). Data suggest that the juxtamembranous region of the cytoplasmic domain participates in protein:protein interactions that allow the low density lipoprotein receptor to cluster in coated pits (2). It has been shown that the family of LDL receptors may serve as viral receptors. Endocytosis of the Flaviviridae viruses, hepatitis C virus, GB virus C/hepatitis G virus, and bovine viral diarrheal virus (BVDV) was shown to be mediated by LDL receptors on cultured cells

UniProt: P01130

Pathways: Hepatitis C, Lipid Metabolism