DLL4 Antikörper (AA 423-650)
Kurzübersicht für DLL4 Antikörper (AA 423-650) (ABIN5027156)
Target
Alle DLL4 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 423-650
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Aufreinigung
- Protein A Chromatography
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Immunogen
- A partial length recombinant DLL4 protein (amino acids 423-650) was used as the immunogen for this antibody.
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Isotyp
- IgG
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Applikationshinweise
- WB: 2-4 μg/mL
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 0.5 mg/mL
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Buffer
- PBS containing 0.05 % BSA, PH 7.4
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C/-20 °C
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Informationen zur Lagerung
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
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- DLL4 (delta-Like 4 (DLL4))
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Andere Bezeichnung
- DLL4
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Hintergrund
- Dll4 (Delta-like 4), a membrane-bound Notch ligand, plays a fundamental role in vascular development and angiogenesis. It is highly expressed in capillary endothelial tip cells and is involved in suppressing neighboring stalk cells to become tip cells during angiogenesis. Dll4-Notch signaling is mediated either by direct cell-cell contact or by Dll4-containing exosomes from a distance. DLL4 signaling is extensively critical for tumor angiogenesis. Blockage of DLL4 signaling inhibits tumor growth by deregulating angiogenesis and promoting non productive angiogenesis. Additionally, DLL4 has been shown to help regulate the cellular actions of VEGF.
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Molekulargewicht
- 75 kDa
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Gen-ID
- 54567
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UniProt
- Q9NR61
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Pathways
- Notch Signalweg
Target
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