CYLD Antikörper (AA 1-230)

Produktnummer ABIN5027126

Dieses Anti-CYLD-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CYLD in WB. Geeignet für Human.

Kurzübersicht für CYLD Antikörper (AA 1-230) (ABIN5027126)

Target: CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CYLD Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CYLD Antikörper

Bindungsspezifität: AA 1-230

Aufreinigung: Protein A Chromatography

Immunogen: A partial length recombinant CYLD protein (amino acids 1-230 ) was used as the immunogen for this antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 2-4 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu CYLD

Target: CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))

Andere Bezeichnung: CYLD

Hintergrund: CYLD (Ubiquitin carboxyl-terminal hydrolase) belongs to peptidase C19 family with 956 amino acids. It is a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains which function as a deubiquitinating enzyme which specifically cleaves 'Lys-63'-linked polyubiquitin chains and 1 ubiquitin-specific proteases (USP) domain. CYLD plays an important role in the regulation of pathways leading to NF-kappa-B activation, proliferation and differentiation. It also interacts with (via CAP-Gly domain) IKBKG/NEMO (via proline-rich C-terminal region). CYLD is important for the survival of immature natural killer cells whereas it is not required for the maturation of intrathymic natural killer cells. It is detected in fetal brain, testis and skeletal muscle, and at a lower level in adult brain, leukocytes, liver, heart, kidney, spleen, ovary and lung. Isoform 2 is found in all tissues except kidney. CYLD related diseases are multiple familial trichoepithelioma 1 and familial cylindromatosis.

Molekulargewicht: 105 kDa

Gen-ID: 1540

UniProt: Q9NQC7

Pathways: Apoptose, Activation of Innate immune Response