MME Antikörper (AA 282-496)

Produktnummer ABIN5027077

Produktdetails anti-MME Antikörper

Target: MME (Membrane Metallo-Endopeptidase (MME))

Bindungsspezifität: AA 282-496

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MME Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Aufreinigung: Protein G Chromatography

Immunogen: A partial length recombinant CD10 protein (amino acids 282-496) was used as the immunogen for this antibody.

Klon: ABM4A52

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise: WB: 0.5-1 μg/mL, IHC: 5-10 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu MME

Target: MME (Membrane Metallo-Endopeptidase (MME))

Andere Bezeichnung: CD10 (MME Produkte)

Synonyme: CALLA antikoerper, CD10 antikoerper, NEP antikoerper, SFE antikoerper, 6030454K05Rik antikoerper, C85356 antikoerper, Nep antikoerper, neprilysin antikoerper, membrane metalloendopeptidase antikoerper, membrane metallo endopeptidase antikoerper, membrane metallo-endopeptidase antikoerper, MME antikoerper, Mme antikoerper

Substanzklasse: Chemical

Hintergrund: CD10, also known as membrane metalloendopeptidase, neutral endopeptidase, neprilysin and common acute lymphoblastic leukaemia antigen (CALLA), is a zinc-dependent metalloendoprotease that cleaves signaling peptides. It is widely expressed in various normal tissues and in epithelial, stromal or both components of various malignancies. CD10 is a marker for intestinal epithelial brush border. It is also present in normal bile ducts and gallbladder epithelia but is absent in cholangiocarcinomas. It is con-sidered as the prototype of this family of membrane-bound, zinc-dependent endopeptidases, which regulate the physiological action of various peptides by lowering their extracellular concentration available for receptor binding. CD10 is also known to be an amyloid b-peptide (Ab) degrading enzyme. Polymorphisms in the CD10 gene increase the risk for Alzheimer disease. Outside the nervous system, it is present on the surface of neutrophils and regulates their activation by degradation of in ammatory peptides.

Molekulargewicht: 97 kDa

Gen-ID: 4311

UniProt: P08473

Pathways: RTK Signalweg, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration