ATG16L1 Antikörper (AA 35-260)

Produktnummer ABIN5027029

Der Kaninchen Polyklonal Anti-ATG16L1-Antikörper wurde für WB validiert. Er ist geeignet, ATG16L1 in Proben von Human zu detektieren.

Kurzübersicht für ATG16L1 Antikörper (AA 35-260) (ABIN5027029)

Target: ATG16L1 (ATG16 Autophagy Related 16-Like 1 (ATG16L1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATG16L1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ATG16L1 Antikörper

Bindungsspezifität: AA 35-260

Aufreinigung: Protein A Chromatography

Immunogen: A partial length recombinant APG16L protein (amino acids 35-260) was used as the immunogen for this antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 2-4 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu ATG16L1

Target: ATG16L1 (ATG16 Autophagy Related 16-Like 1 (ATG16L1))

Andere Bezeichnung: APG16L

Hintergrund: ATG16L1/APG16L is part of a large protein complex that functions as a molecular scaffold mediating protein-protein interactions necessary for formation of the autophagosome in response to both classical and pathogen-related autophagy stimuli. APG16L protein contains an N-terminal Atg5-binding domain, a coiled-coil domain and a C-terminal WD (tryptophan-aspartic acid)-repeat domain. APG16L forms a complex with the Atg12 Atg5 conjugate and together they are actively translocated to the phagophore and are further elongated during autophagosome formation. Genetic variation in the APG16L gene has been recently implicated in Crohn's disease pathogenesis. Polymorphism within APG16L gene results in excessive production of IL-1beta and IL-6 culmunating in the inflammatory process in Crohn's disease.

Molekulargewicht: 53 kDa (Isoform)

Gen-ID: 55054

UniProt: Q676U5

Pathways: Autophagie