UCMA Antikörper (C-Term)

Produktnummer ABIN501098

Der Kaninchen Polyklonal anti-UCMA Antikörper wird verwendet zum Nachweis von UCMA in Proben von Human und Maus. Er wurde validiert für WB und EIA.

Kurzübersicht für UCMA Antikörper (C-Term) (ABIN501098)

Target: UCMA (Upper Zone of Growth Plate and Cartilage Matrix Associated (UCMA))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UCMA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-UCMA Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody detects UCMA.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse

Aufreinigung: Affinity chromatography

Immunogen: UCMA antibody was raised against a 16 amino acid peptide near the carboxy terminus of human UCMA.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 2.5 - 5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu UCMA

Target: UCMA (Upper Zone of Growth Plate and Cartilage Matrix Associated (UCMA))

Andere Bezeichnung: UCMA

Hintergrund: UCMA is a secreted cartilage-specific protein that was discovered in a screen for differentially expressed genes in retinoic acid-treated mouse chondrocytes. It was also identified in a human chondrocyte EST screen for candidate genes of skeletal dysplasias. UCMA expression is thought to parallel that of collagen II with its expression decreasing with maturation chrondrocytes mature. UCMA is processed by a furin-like protease into two fragments, an amino-terminal fragment and a carboxy-terminal fragment (UCMA-C). Application of recombinant UCMA-C to primary osteoblasts, mesenchymal stem cells, and MC3T3-E1 pre-osteoblasts interferes with their osteogenic differentiation, but does not affect expression of chondrocyte-specific genes or chondrocyte proliferation, suggesting that UCMA may be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells. At least two isoforms of UCMA are known to exist.Synonyms: C10orf49, Unique cartilage matrix-associated protein

Gen-ID: 221044

NCBI Accession: NP_660357