TRIM5 Antikörper (Isoform alpha, Middle Region)

Produktnummer ABIN501052

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch TRIM5 in WB, IHC (p) und EIA. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für TRIM5 Antikörper (Isoform alpha, Middle Region) (ABIN501052)

Target: TRIM5 (Tripartite Motif Containing 5 (TRIM5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRIM5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-TRIM5 Antikörper

Bindungsspezifität: Isoform alpha, Middle Region

Spezifität: This antibody detects TRIM5 / RNF88 alpha at Center.

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Peptide affinity chromatography

Immunogen: TRIM5 alpha antibody was raised against a synthetic peptide corresponding to amino acids near the mid-region of human TRIM5 alpha.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 1 to 2 μg/mL. A band at approximately 55 kDa can be detected. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu TRIM5

Target: TRIM5 (Tripartite Motif Containing 5 (TRIM5))

Andere Bezeichnung: TRIM5 / RNF88

Hintergrund: TRIM5 is a member of a broad family of otherwise unrelated proteins defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region . TRIM5 has six alternately spliced isoforms, the longest of which is the alpha variant which also contains a carboxy-terminal B30.2 (SPRY) domain. Expression of TRIM5alpha variants from humans, rhesus monkeys, and African green monkeys enabled resistance to infection by various retroviruses including HIV-1, albeit at differing efficiencies. All TRIM5alpha variants could inhibit at least two different retroviruses, but not from those viruses isolated from the same species, suggesting that TRIM5alpha acts as a natural barrier to cross-species retrovirus transmission.Synonyms: RING finger protein 88, Tripartite motif-containing protein 5

Gen-ID: 85363

NCBI Accession: NP_149023

Pathways: Activation of Innate immune Response