RAD21 Antikörper (AA 531-631) (AbBy Fluor® 680)

Produktnummer ABIN5009508

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch RAD21 in WB, FACS, IF (cc) und IF (p). Er zeigt eine Reaktivität gegenüber Human und Ratte.

Kurzübersicht für RAD21 Antikörper (AA 531-631) (AbBy Fluor® 680) (ABIN5009508)

Target: RAD21 (RAD21 Homolog (RAD21))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAD21 Antikörper ist konjugiert mit AbBy Fluor® 680

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-RAD21 Antikörper (AbBy Fluor® 680)

Bindungsspezifität: AA 531-631

Kreuzreaktivität: Human, Ratte

Homologie: Mouse,Dog,Cow,Pig,Horse,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Rad2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu RAD21

Target: RAD21 (RAD21 Homolog (RAD21))

Andere Bezeichnung: RAD21

Hintergrund:

Synonyms: HR21, MCD1, NXP1, SCC1, CDLS4, hHR21, HRAD21, Double-strand-break repair protein rad21 homolog, Nuclear matrix protein 1, NXP-1, SCC1 homolog, RAD21, KIAA0078

Background: Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway.

Gen-ID: 5885

UniProt: O60216

Pathways: Positive Regulation of Endopeptidase Activity