TARDBP Antikörper (Center)

Produktnummer ABIN500883

Dieses Anti-TARDBP-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TARDBP in WB, IF und EIA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für TARDBP Antikörper (Center) (ABIN500883)

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TARDBP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Produktdetails anti-TARDBP Antikörper

Bindungsspezifität: Center

Spezifität: At least two isoforms are known to exist for this protein, this TDP43 antibody only recongizes the longer of the two isoforms.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Peptide affinity chromatography

Immunogen: TDP43 antibody was raised against a 18 amino acid peptide from near the center of human TDP43.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 0.5 - 1 μg/mL. Immunoflourescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody (in aliquots) at -20 °C.

Details zu TARDBP

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Andere Bezeichnung: TARDBP

Hintergrund: TDP43 was initially identified as a novel cellular protein that bound to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3' splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences. At least two isoforms are known to exist for this protein, this TDP43 antibody only recongizes the longer of the two isoforms.Synonyms: TAR DNA-binding protein 43, TDP-43, TDP43

Gen-ID: 23435

NCBI Accession: NP_031401

Pathways: Positive Regulation of Peptide Hormone Secretion