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ADAM17 Antikörper (C-Term)

Der Kaninchen Polyklonal Anti-ADAM17-Antikörper wurde für WB, IF und EIA validiert. Er ist geeignet, ADAM17 in Proben von Human, Ratte und Maus zu detektieren. Es ist 1 Publikation verfügbar.
Produktnummer ABIN500861

Kurzübersicht für ADAM17 Antikörper (C-Term) (ABIN500861)

Target

Alle ADAM17 Antikörper anzeigen
ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

Reaktivität

  • 111
  • 49
  • 46
  • 3
  • 3
  • 3
  • 1
Human, Ratte, Maus

Wirt

  • 91
  • 22
  • 1
  • 1
  • 1
  • 1
Kaninchen

Klonalität

  • 82
  • 35
Polyklonal

Konjugat

  • 63
  • 8
  • 7
  • 5
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser ADAM17 Antikörper ist unkonjugiert

Applikation

  • 89
  • 48
  • 39
  • 22
  • 19
  • 15
  • 14
  • 12
  • 12
  • 10
  • 4
  • 3
  • 3
  • 2
  • 1
Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
  • Bindungsspezifität

    • 16
    • 10
    • 8
    • 7
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Spezifität

    This antibody detects CD156b / ADAM17 at C-term. 80 to 130 kDa bands can be detected, which may represent mature protein, precursor, and glycosylated CD156b.

    Kreuzreaktivität (Details)

    Species reactivity (tested):Human, Mouse, Rat.

    Aufreinigung

    Immunoaffinity Chromatography

    Immunogen

    A peptide corresponding to amino acids near the carboxy terminus of Human CD156b / ADAM17

    Isotyp

    IgG
  • Applikationshinweise

    ELISA. Western blot: 1: 500 to 1: 2000. Immunoflourescence.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Buffer

    PBS containing 0.02 % Sodium Azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C/-20 °C

    Informationen zur Lagerung

    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Wang, Wang, Yin, Zhang, Yu, Kong, Yuan, Fang, Liu, Liu, Shi: "Reduced neurotrophic factor level is the early event before the functional neuronal deficiency in high-fat diet induced obese mice." in: Metabolic brain disease, Vol. 32, Issue 1, pp. 247-257, (2018) (PubMed).

  • Target

    ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

    Andere Bezeichnung

    CD156b / ADAM17

    Hintergrund

    Tumor-necrosis factor-a is a proinflammatory cytokine and contributes to a variety of inflammatory disease responses and programmed cell death. TNF-alpha is synthesized as a 26K type II membrane-bound precursor that is cleaved by a convertase to generate secreted 17K mature TNF-alpha. TNF-alpha converting enzyme (TACE) protein was recently purified and the human and mouse TACE cDNAs were cloned by several groups separately. TACE is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease). TACE also processes other cell surface proteins, including TNF receptor, TGFa, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP) (4,5). TACE mRNA is expressed in a variety of human and murine tissues. TACE was selected as one of the few targets in cytokine activation by the Eighth International Conference of the Inflammation Research Association.Synonyms: CSVP, Disintegrin and metalloproteinase domain-containing protein 17, Snake venom-like protease, TACE, TNF-alpha convertase, TNF-alpha-converting enzyme

    Gen-ID

    6868

    NCBI Accession

    NP_003174

    Pathways

    Notch Signalweg, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Response to Growth Hormone Stimulus
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