MYLK3 Antikörper (AbBy Fluor® 750)

Produktnummer ABIN5007208

Der Kaninchen Polyklonal Anti-MYLK3-Antikörper wurde für WB validiert. Er ist geeignet, MYLK3 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für MYLK3 Antikörper (AbBy Fluor® 750) (ABIN5007208)

Target: MYLK3 (Myosin Light Chain Kinase 3 (MYLK3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MYLK3 Antikörper ist konjugiert mit AbBy Fluor® 750

Applikation: Western Blotting (WB)

Produktdetails anti-MYLK3 Antikörper (AbBy Fluor® 750)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MYLK3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu MYLK3

Target: MYLK3 (Myosin Light Chain Kinase 3 (MYLK3))

Andere Bezeichnung: MYLK3

Hintergrund:

Synonyms: caMLCK, Cardiac MyBP C associated Ca/CaM kinase, Cardiac-MyBP-C-associated Ca/CaM kinase, MLC kinase, MLCK, MLCK2, Mylk3, MYLK3_HUMAN, Myosin light chain kinase 3, Putative myosin light chain kinase 3.

Background: The Ca2+/calmodulin-dependent protein kinases (CaM kinases) are a structurally related subfamily of serine/threonine kinases that includes CaMKI, CaMKII, CaMKIV and Myosin light chain kinases (MYLKs, also designated MLCKs). The MYLK kinases phosphorylate Myosin regulatory light chains to catalyze Myosin interaction with Actin filaments, resulting in contractile activity. MYLK3 (Myosin light chain kinase 3) is a 795 amino acid cardiac-specific protein that contains one protein kinase domain and belongs to the protein kinase superfamily. Like other MYLK kinases, MYLK3 is thought to play a role in smooth muscle contraction, specifically using magnesium as a cofactor to catalyze the ATP-dependent phosphorylation of Myosin light chain proteins. Additionally, MYLK3 may regulate sarcomere assembly in heart tissue, possibly mediating proper heart function.

Pathways: Regulation of Muscle Cell Differentiation