beta Catenin Antikörper (pSer45, pThr41) (AbBy Fluor® 680)

Produktnummer ABIN4997393

Dieses Anti-beta Catenin-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von beta Catenin in FACS, IF (cc) und IF (p). Geeignet für Human und Ratte.

Kurzübersicht für beta Catenin Antikörper (pSer45, pThr41) (AbBy Fluor® 680) (ABIN4997393)

Target: beta Catenin (CATNB) (Catenin, beta (CATNB))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser beta Catenin Antikörper ist konjugiert mit AbBy Fluor® 680

Applikation: Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-beta Catenin Antikörper (AbBy Fluor® 680)

Bindungsspezifität: pSer45, pThr41

Spezifität: This phophorylation site is homologous to that of Thr41 + Ser45 in Mouse and Rat.

Kreuzreaktivität: Human, Ratte

Homologie: Mouse,Cow,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human Beta-Catenin around the phosphorylation site of Thr41/Ser45

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu beta Catenin

Target: beta Catenin (CATNB) (Catenin, beta (CATNB))

Andere Bezeichnung: Beta Catenin +

Hintergrund:

Synonyms: CTNNB, MRD19, armadillo, Catenin beta-1, Beta-catenin, CTNNB1, OK/SW-cl.35, PRO2286

Background: Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML.

Gen-ID: 1499

UniProt: P35222

Pathways: Peptide Hormone Metabolism