APOB Antikörper (AA 1540-1590) (AbBy Fluor® 750)

Produktnummer ABIN4996693

Der Kaninchen Polyklonal Anti-APOB-Antikörper wurde für WB validiert. Er ist geeignet, APOB in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für APOB Antikörper (AA 1540-1590) (AbBy Fluor® 750) (ABIN4996693)

Target: APOB (Apolipoprotein B (APOB))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser APOB Antikörper ist konjugiert mit AbBy Fluor® 750

Applikation: Western Blotting (WB)

Produktdetails anti-APOB Antikörper (AbBy Fluor® 750)

Bindungsspezifität: AA 1540-1590

Homologie: Human,Mouse,Rat,Dog,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Apolipoprotein B

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu APOB

Target: APOB (Apolipoprotein B (APOB))

Andere Bezeichnung: ApoB

Hintergrund:

Synonyms: Apo B 100, Apo B, Apo B-100, Apo B-48, ApoB 100, ApoB 48, ApoB, APOB protein, APOB_HUMAN, Apolipoprotein B 100, Apolipoprotein B 48, Apolipoprotein B, Apolipoprotein B-48, FLDB.

Background: Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.Involvement in disease: Defects in APOB are a cause of hypobetalipoproteinemia familial type 1 (FHBL1) . A disorder characterized by highly reduced plasma concentrations of low density lipoproteins, and dietary fat malabsorption. Clinical presentation may vary from no symptoms to severe gastrointestinal and neurological dysfunction similar to abetalipoproteinemia.Defects in APOB are a cause of familial ligand-defective apolipoprotein B-100 (FDB). FDB is a dominantly inherited disorder of lipoprotein metabolism leading to hypercholesterolemia and increased proneness to coronary artery disease (CAD). The plasma cholesterol levels are dramatically elevated due to impaired clearance of LDL particles by defective APOB/E receptors.

Gen-ID: 338

Pathways: Lipid Metabolism