CHEK2 Antikörper (N-Term)

Produktnummer ABIN499619

Der Kaninchen Polyklonal Anti-CHEK2-Antikörper wurde für WB, IF und EIA validiert. Er ist geeignet, CHEK2 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für CHEK2 Antikörper (N-Term) (ABIN499619)

Target: CHEK2 (Checkpoint Kinase 2 (CHEK2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CHEK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Produktdetails anti-CHEK2 Antikörper

Bindungsspezifität: N-Term

Spezifität: Chk2 antibody was raised against a synthetic peptide corresponding to amino acids near the amino terminus of human Chk2.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: Human Chk2 (N-Terminus) Peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: Chk2 antibody can be used for detection of Chk2 at 0.5 to 1 μg/mL. A 60 kDaband can be detected. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu CHEK2

Target: CHEK2 (Checkpoint Kinase 2 (CHEK2))

Andere Bezeichnung: CHK2

Hintergrund: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including Chk2 , p53R2 (2), p53AIP1 (3), Noxa (4), PIDD (5), and PID/MTA2 (6), were recently discovered. The checkpoint kinase Chk2 is the mammalian homologue of yeast Cds1/Rad53. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 (7,8). Chk2 serves as ATM downstream effector to mediate activation of p53. Chk2 also phosphorylates and activates BRCA1, the product of a tumor suppressor gene that is mutated in breast and ovarian cancer (9).Synonyms: CHEK-2, CHEK2, CHK-2, CHK2 checkpoint homolog, Cds1, RAD53, Serine/threonine-protein kinase Chk2

Gen-ID: 11200

NCBI Accession: NP_009125

UniProt: O96017

Pathways: p53 Signalweg, Apoptose, Zellzyklus