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GRB2 Antikörper
GRB2
Reaktivität: Human, Maus, Ratte
WB
Wirt: Kaninchen
Polyclonal
unconjugated
Produktdetails anti-GRB2 Antikörper
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Target
Alle GRB2 Antikörper anzeigen
GRB2
(Growth Factor Receptor-Bound Protein 2 (GRB2))
Reaktivität
Alle Reaktivitäten für GRB2 Antikörper
Human, Maus, Ratte
Wirt
Alle Wirte für GRB2 Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für GRB2 Antikörper
Polyklonal
Konjugat
Alle Konjugate für GRB2 Antikörper
Dieser GRB2 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für GRB2 Antikörper
Western Blotting (WB)
Spezifität
This antibody detects endogenous levels of GRB2 protein. (region surrounding Arg178)
Kreuzreaktivität (Details)
Species reactivity (expected):Mouse and Rat. Species reactivity (tested):Human.
Aufreinigung
Affinity chromatography using epitope-specific immunogen
Reinheit
> 95 % pure by SDS-PAGE
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Discover our top product GRB2 Primärantikörper
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Anwendungsinformationen
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Applikationshinweise
Western blot: 1: 500 - 1: 1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Konzentration
1.0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Details zu GRB2
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Target
GRB2
(Growth Factor Receptor-Bound Protein 2 (GRB2))
Andere Bezeichnung
GRB2 / ASH (GRB2 Produkte )
Synonyme
GRB2 antikoerper, grb2 antikoerper, AA408164 antikoerper, Ash antikoerper, ASH antikoerper, EGFRBP-GRB2 antikoerper, Grb3-3 antikoerper, MST084 antikoerper, MSTP084 antikoerper, NCKAP2 antikoerper, wu:fb18e12 antikoerper, wu:fb34e06 antikoerper, zgc:73077 antikoerper, growth factor receptor bound protein 2 antikoerper, growth factor receptor-bound protein 2 antikoerper, growth factor receptor-bound protein 2b antikoerper, GRB2 antikoerper, grb2 antikoerper, Grb2 antikoerper, grb2b antikoerper
Hintergrund
Growth factor receptor bound protein 2 (GRB2), also known as Ash protein, is a 24 kDa protein that contains a central Src homology (SH2) domain flanked by two SH3 domains. GRB2 is believed to be a regulatory subunit of signaling molecules whose activity is modulated by receptor binding. GRB2 associates with activated (tyrosine phosphorylated) EGFR and PDGFR via its SH2 domain as well as IRS1, SHC, and LNK through SH2 and SH3 domains. The SH3 domain binds to SOS, a guanine nucleotide exchange factor for Ras proteins. Endocytosis of activated EGFR requires the interaction of GRB2 with the GTP binding protein dynamin, a factor essential to the formation of endocytotic vesicle. It is ubiquitously expressed and several isoforms are produced by alternative splicing. On SDS PAGE, GRB2 has an apparent molecular weight of 28 kDa.Synonyms: Growth factor receptor-bound protein 2
Molekulargewicht
approx. 32 kDa
Gen-ID
2885
NCBI Accession
NP_002077
UniProt
P62993
Pathways
RTK Signalweg , T-Zell Rezeptor Signalweg , Fc-epsilon Rezeptor Signalübertragung , EGFR Signaling Pathway , Neurotrophin Signalübertragung , Regulation of Actin Filament Polymerization , Hepatitis C , Signaling Events mediated by VEGFR1 and VEGFR2 , Signaling of Hepatocyte Growth Factor Receptor , EGFR Downregulation
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