TAL1 Antikörper

Produktnummer ABIN499039

Produktdetails anti-TAL1 Antikörper

Target: TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TAL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of TAL1 protein. (region surrounding Gly116)

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse.

Aufreinigung: Affinity Chromatography using epitope-specific immunogen.

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu TAL1

Target: TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))

Andere Bezeichnung: TAL1 (TAL1 Produkte)

Synonyme: SCL/tal-1 antikoerper, Scl antikoerper, bHLHa17 antikoerper, tal-1 antikoerper, SCL antikoerper, TCL5 antikoerper, scl antikoerper, tcl5 antikoerper, SCL-alpha antikoerper, SCL-beta antikoerper, scl/tal1 antikoerper, zgc:85605 antikoerper, T cell acute lymphocytic leukemia 1 antikoerper, TAL bHLH transcription factor 1, erythroid differentiation factor antikoerper, T-cell acute lymphocytic leukemia 1 S homeolog antikoerper, T-cell acute lymphocytic leukemia 1 antikoerper, Tal1 antikoerper, TAL1 antikoerper, tal1.S antikoerper, tal1 antikoerper

Hintergrund: Activation of TAL1 characterizes up to 60 % of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase IIalpha, a serine/ threonine protein kinase known to modulate the activity of other bHLH transcription factors.Synonyms: SCL, Stem cell protein, T-cell acute lymphocytic leukemia protein 1, T-cell leukemia/lymphoma protein 5, TAL-1, TCL5

Molekulargewicht: approx. 45 kDa

Gen-ID: 6886

NCBI Accession: NP_003180

UniProt: P17542

Pathways: Stem Cell Maintenance