NFKBIB Antikörper

Produktnummer ABIN498987

Der Kaninchen Polyklonal anti-NFKBIB Antikörper (ABIN498987) detektiert spezifisch NFKBIB in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für NFKBIB Antikörper (ABIN498987)

Target: NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NFKBIB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-NFKBIB Antikörper

Spezifität: This antibody detects endogenous levels of IkappaB-beta protein. (region surrounding Ala13)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography

Reinheit: > 95 % by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu NFKBIB

Target: NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))

Andere Bezeichnung: NFKBIB / IKBB

Hintergrund: Three major forms of IkappaB-like molecules have been identified and each is characterized by multiple copies of ankyrin repeats. IkappaB-alpha and IkappaB-beta appear to be the major regulatory forms of IkappaB in most cells. These proteins interact with p65 or c-Rel containing forms of NFkappaB and block nuclear import by masking the nuclear localization sequences of NFkappaB. The activation of NFkB involves the inducible phosphorylation and subsequent degradation of IkappaB. Immunoblotting easily detects the hyper-phosphorylated forms of IkappaB-alpha, but not phosphorylated IkappaB-beta.Synonyms: I-kappa-B-beta, IkB-B, IkB-beta, IkappaBbeta, NF-kappa-B inhibitor beta, TR-interacting protein 9, TRIP9, Thyroid receptor-interacting protein 9

Molekulargewicht: approx. 37 kDa

Gen-ID: 4793

NCBI Accession: NP_001001716

UniProt: Q15653

Pathways: NF-kappaB Signalweg, Activation of Innate immune Response, Maintenance of Protein Location, Toll-Like Receptors Cascades