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KIT Antikörper (pTyr721)
KIT
Reaktivität: Human, Maus, Ratte
WB
Wirt: Kaninchen
Polyclonal
unconjugated
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Target
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KIT
(Mast/stem Cell Growth Factor Receptor (KIT))
Bindungsspezifität
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pTyr721
Reaktivität
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Human, Maus, Ratte
Wirt
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Kaninchen
Klonalität
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Polyklonal
Konjugat
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Dieser KIT Antikörper ist unkonjugiert
Applikation
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Western Blotting (WB)
Spezifität
This antibody detects endogenous levels of p-c-Kit protein, only when phosphorylated at Tyr721.
Kreuzreaktivität (Details)
Species reactivity (expected):Mouse and Rat. Species reactivity (tested):Human.
Aufreinigung
Affinity chromatography
Reinheit
> 95 % by SDS-PAGE
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Applikationshinweise
Western Blot: 1/500 - 1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Konzentration
1,0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Details zu KIT
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Target
KIT
(Mast/stem Cell Growth Factor Receptor (KIT))
Andere Bezeichnung
CD117 / C-Kit (KIT Produkte )
Synonyme
C-Kit antikoerper, CD117 antikoerper, PBT antikoerper, SCFR antikoerper, Bs antikoerper, Fdc antikoerper, Gsfsco1 antikoerper, Gsfsco5 antikoerper, Gsfsow3 antikoerper, SCO1 antikoerper, SCO5 antikoerper, SOW3 antikoerper, Ssm antikoerper, Tr-kit antikoerper, W antikoerper, c-KIT antikoerper, c-kit antikoerper, MGF antikoerper, KIT antikoerper, C-KIT antikoerper, kit antikoerper, receptor antikoerper, sparse antikoerper, Xkl-1 antikoerper, kit-a antikoerper, kit-b antikoerper, kl1-A antikoerper, krk1 antikoerper, pbt antikoerper, scfr antikoerper, KIT proto-oncogene receptor tyrosine kinase antikoerper, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a antikoerper, KIT proto-oncogene receptor tyrosine kinase S homeolog antikoerper, KIT antikoerper, Kit antikoerper, kita antikoerper, kit antikoerper, kit.S antikoerper
Hintergrund
The c-Kit proto-oncogene has been identified as a member of the receptor tyrosine kinase family and more specifically has been shown to be closely related to the platelet derived growth factor receptor (PDGFR). c-Kit, the normal cellular homolog of the HZ4-feline sarcoma virus transforming gene v-Kit, encodes a transmembrane receptor with a molecular weight of 145- 160 kDa. c-Kit has also been show to be identical with the product of the W locus in mice and as such is integral to the development of mast cells and hematopoiesis. The ligand for the c-Kit receptor (KL) has been identified and shown to be encoded at the murine steel (SI) locus. Two sites on c-Kit are able to bind SH2(CHK), the Tyr 568/570 diphosphorylated sequence and the monophosphorylated Tyr 721 sequence.Synonyms: KIT, Mast/stem cell growth factor receptor, Proto-Oncogene Tyrosine-Protein Kinase, SCFR
Molekulargewicht
approx. 120,145 kDa
Gen-ID
3815
NCBI Accession
NP_000213
UniProt
P10721
Pathways
RTK Signalweg , Fc-epsilon Rezeptor Signalübertragung , EGFR Signaling Pathway , Neurotrophin Signalübertragung , Sensory Perception of Sound , Stem Cell Maintenance , Production of Molecular Mediator of Immune Response , Regulation of long-term Neuronal Synaptic Plasticity
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